Cross relationships among 37 rhinoviruses demonstrated by virus neutralization with potent monotypic rabbit antisera.

Infection and immunity ·Vol. 7 ·No. 3 ·1973-03-00 ·Pages 335-40

Cooney MK, Kenny GE, Tam R, Fox JP

Abstract

Antisera produced in rabbits to 37 rhinovirus (RV) types have been examined for antibody to the 36 corresponding heterologous types. Reciprocal neutralization was noted between RV types 2 and 49 and RV types 13 and 41. Five additional monotypic rhinoviral rabbit antisera neutralized one heterologous rhinovirus. Neutralizing antibody titers against heterologous RV serotypes were similar to those shown in the RV 1A, 1B and RV 9, 32 reciprocal cross-reactions, and would not be expected to result in false identification of serotypes. Comparison of neutralizing antibody titers and neutralization rate constants in serial serum specimens of immunized rabbits showed that antibody response to the immunizing RV type and the cross-reacting type followed a similar time pattern.

MeSH Terms

Animals Antibodies, Viral/analysis Antibody Specificity Cross Reactions Immune Sera Neutralization Tests Rabbits/immunology Rhinovirus/immunology

Chemicals

Antibodies, Viral Immune Sera

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Cooney M K

Kenny G E

Tam R

Fox J P

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.7.3.335-340.1973

Published

1973-03-00

Pages

335-40

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422680

Subset

External Links

PubMed source DOI: 10.1128/iai.7.3.335-340.1973 PMC Full Text View journal details

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Cross relationships among 37 rhinoviruses demonstrated by virus neutralization with potent monotypic rabbit antisera.

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