Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.

Infection and immunity ·Vol. 6 ·No. 5 ·1972-11-00 ·Pages 743-7

Stringfellow DA, Glasgow LA

Abstract

Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.

MeSH Terms

Animals Antiviral Agents/therapeutic use Fibroblasts/microbiology Interferon Inducers/therapeutic use Interferons/blood L Cells Mice Newcastle disease virus/immunology Poly I-C/pharmacology Vesicular stomatitis Indiana virus/immunology Viral Plaque Assay

Chemicals

Antiviral Agents Interferon Inducers Interferons Poly I-C

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stringfellow D A

Glasgow L A

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.6.5.743-747.1972

Published

1972-11-00

Pages

743-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422604

Subset

External Links

PubMed source DOI: 10.1128/iai.6.5.743-747.1972 PMC Full Text View journal details

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Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.

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