Inhibition by -amanitin of simian virus 40-specific ribonucleic acid synthesis in nuclei of infected monkey cells.

Journal of virology ·Vol. 10 ·No. 5 ·1972-11-00 ·Pages 1086-9

Jackson AH, Sugden B

Abstract

Conditions affecting the synthesis of simian virus 40-specific ribonucleic acid (RNA) in nuclei isolated from lytically infected cells were investigated. Deoxyribonucleic acid-RNA hybridization results show that an alpha-amanitin-sensitive RNA polymerase activity is responsible for transcription of simian virus 40 deoxyribonucleic acid.

MeSH Terms

Animals Cell Line Cell Nucleus/metabolism Cells, Cultured DNA Replication DNA, Viral/biosynthesis DNA-Directed RNA Polymerases/metabolism Haplorhini Kidney Mycotoxins/pharmacology Nucleic Acid Hybridization Peptides/pharmacology RNA/biosynthesis RNA, Viral/antagonists & inhibitors,biosynthesis Simian virus 40/metabolism Transcription, Genetic Tritium Uracil Nucleotides/metabolism

Chemicals

DNA, Viral Mycotoxins Peptides RNA, Viral Uracil Nucleotides Tritium RNA DNA-Directed RNA Polymerases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jackson A H

Sugden B

References (11)

11 references, click to expand

Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei.
Biochem J. 1967 Nov;105(2):779-82 PMID: 5584017
Characteristics of the syrian hamster ribonucleic acid present in cells transformed by polyoma, simian virus 40, or adenovirus 12.
J Virol. 1969 Feb;3(2):119-25 PMID: 4304441
Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms.
Nature. 1969 Oct 18;224(5216):234-7 PMID: 5344598
Encapsidation of free host DNA by simian virus 40: a simian virus 40 pseudovirus.
Science. 1970 Apr 10;168(3928):268-71 PMID: 4313909
Specific nucleolar and nucleoplasmic RNA polymerases.
Proc Natl Acad Sci U S A. 1970 Mar;65(3):675-82 PMID: 5267147
SV40 DNA strand selection by Escherichia coli RNA polymerase.
J Mol Biol. 1970 Jun 14;50(2):407-20 PMID: 4320049
Transcription of the adenovirus genome by an -amanitine-sensitive ribonucleic acid polymerase in HeLa cells.
J Virol. 1972 Apr;9(4):621-6 PMID: 5021308
State of adenovirus 2 deoxyribonucleic acid in the nucleus and its mode of transcription: studies with isolated viral deoxyribonucleic acid-protein complexes and isolated nuclei.
J Virol. 1972 Apr;9(4):627-35 PMID: 5021309
Strand orientation of simian virus 40 transcription in productively infected cells.
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1517-20 PMID: 4338596
Plaque formation and isolation of pure lines with poliomyelitis viruses.
J Exp Med. 1954 Feb;99(2):167-82 PMID: 13130792
Plaque production by the polyoma virus.
Virology. 1959 Jul;8(3):396-7 PMID: 13669362

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.10.5.1086-1089.1972

Published

1972-11-00

Pages

1086-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356581

Subset

External Links

PubMed source DOI: 10.1128/JVI.10.5.1086-1089.1972 PMC Full Text View journal details

Analysis Services

Inhibition by -amanitin of simian virus 40-specific ribonucleic acid synthesis in nuclei of infected monkey cells.

Contact

WeChat Official Account