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PMID: 4343993 Published · ppublish English Journal Article

Giant organelles containing tubules in Chediak-Higashi lymphocytes.

The American journal of pathology ·Vol. 69 ·No. 2 ·1972-11-00 ·Pages 225-38

White JG

Abstract

A giant inclusion filled with structures resembling microtubules was observed in the cytoplasm of a small percentage of circulating lymphocytes from 4 children with the Chediak-Higashi syndrome (CHS). The organelles were similar in many respects to tubule-containing inclusions described previously in normal and abnormal lymphocytes. Tubule-filled organelles appear to develop by cytoplasmic sequestration, and their massive size in CHS cells may result from fusion of small organelles to form a single giant inclusion. Acid phosphatase was found only in giant tubular inclusions which had fused with lysosomal granules. The basis for the existence of these organelles in normal and abnormal lymphocytes remains obscure.

MeSH Terms
Acid Phosphatase/analysis Chediak-Higashi Syndrome/blood,pathology Child Cytoplasmic Granules Humans Inclusion Bodies Lymphocytes/enzymology Membranes/pathology Microscopy, Electron Microtubules Organoids
Chemicals
Acid Phosphatase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
White J G
References (24)
24 references, click to expand
  1. Giant granules and widespread cytoplasmic inclusions in a genetic syndrome of Aleutian mink. An electron microscopic study.
    Lab Invest. 1965 Dec;14(12):2063-79 PMID: 5853555
  2. The Chediak-Higashi syndrome: a possible lysosomal disease.
    Blood. 1966 Aug;28(2):143-56 PMID: 5913047
  3. Origin of granules in polymorphonuclear leukocytes. Two types derived from opposite faces of the Golgi complex in developing granulocytes.
    J Cell Biol. 1966 Feb;28(2):277-301 PMID: 5914694
  4. The Chediak-Higashi syndrome: cytoplasmic sequestration in circulating leukocytes.
    Blood. 1967 Apr;29(4):435-51 PMID: 6023060
  5. The circulating lymphocyte--its role in infectious mononucleosis.
    Ann Intern Med. 1968 Aug;69(2):333-59 PMID: 4299188
  6. A new type of inclusion bodies in lymphocytes.
    Scand J Haematol. 1968;5(2):81-96 PMID: 4175220
  7. Electron-microscopical study of bone marrow cells in a case of Chediak-Higashi-Steinbrinck syndrome.
    Br J Haematol. 1968 Aug;15(2):173-6 PMID: 4877512
  8. [A new type of organelle in peripheral lymphocytes?].
    Dtsch Med Wochenschr. 1968 Nov 1;93(44):2099-100 PMID: 5686333
  9. Similarity between leukocyte cultures from cancerous and noncancerous human subjects: an electron microscopic study.
    Cancer Res. 1968 Oct;28(10):1982-9 PMID: 5246715
  10. [Electron microscopic study of the Chediak-Higashi-Steinbrick syndrome].
    Acta Cient Venez. 1967;18(3):73-8 PMID: 5613883
  11. Systemic lupus erythematosus and myxovirus.
    N Engl J Med. 1969 Feb 6;280(6):333 PMID: 5762386
  12. Fine structural studies of leukocytes from patients and heterozygotes with the Chediak-Higashi syndrome.
    Blood. 1969 Apr;33(4):527-40 PMID: 5776200
  13. The Chediak-Higashi syndrome: continuous suspension cultures derived from peripheral blood.
    Blood. 1969 Jun;33(6):821-32 PMID: 4181890
  14. Fine structure of continuous long term lymphoid cell cultures from a Chediak-Higashi patient and heterozygote.
    Lab Invest. 1969 Sep;21(3):225-9 PMID: 5811076
  15. Chediak-Higashi disease. Morphologic studies of a patient and her family.
    Arch Pathol. 1969 Oct;88(4):329-39 PMID: 5822051
  16. Chediak-Higashi syndrome.
    Arch Pathol. 1969 Oct;88(4):340-9 PMID: 5822052
  17. Microtubules of systemic lupus erythematosus.
    Lancet. 1971 Jan 16;1(7690):131-2 PMID: 4099619
  18. Ultrastructure of cells in bone marrow and peripheral blood of normal mink and mink with the homologue of the Chediak-Higashi trait of humans. II. Cytoplasmic granules in eosinophils, basophils, mononuclear cells and platelets.
    Am J Pathol. 1971 Jun;63(3):411-32 PMID: 5104068
  19. Tubular arrays in the endoplasmic reticulum in human tumor cells.
    Lab Invest. 1971 Jun;24(6):492-8 PMID: 4996982
  20. Ultrastructure of bone marrow granulocytes in normal mink and mink with the homolog of the Chediak-Higashi trait of humans. I. Origin of the abnormal granules present in the neutrophils of mink with the C-HS trait.
    Lab Invest. 1971 Apr;24(4):303-17 PMID: 5104888
  21. Intraendothelial inclusions in kidneys of patients with systemic lupus erythematosus.
    Ann Intern Med. 1971 Oct;75(4):537-47 PMID: 4398449
  22. Photosensitive cheilitis. Clinical and pathogenetic considerations.
    Ann Intern Med. 1971 Dec;75(6):909-17 PMID: 5134900
  23. Chronic lymphocytosis with lymphocyte inclusions.
    Ann Intern Med. 1972 Feb;76(2):265-8 PMID: 4333229
  24. [A case of Chediak-Steinbrinck-Higashi disease. Clinical and cytological study].
    Presse Med. 1960 Mar 23;68:563-6 PMID: 13799637
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1972-11-00
Pages
225-38
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032645
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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