A 'virus-free' cell line derived from a patient with infectious mononucleosis.

Journal of clinical pathology ·Vol. 25 ·No. 8 ·1972-08-00 ·Pages 701-4

Marston SD, Almond EJ, Bishun NP, Maunsell ED, Sutton RN

Abstract

A continuous cell culture line, derived from a nurse with infectious mononucleosis, is described. Electron microscopic and immunofluorescent examination suggested that it was substantially free from detectable complete virus particles, although the presence of a soluble complement-fixing antigen showed the persistence of other antigenic components of the EB virus.

MeSH Terms

Adult Antibodies, Viral Antigens, Viral Cell Line Complement Fixation Tests Female Fluorescent Antibody Technique Herpesvirus 4, Human/isolation & purification Humans Infectious Mononucleosis/immunology,microbiology Microscopy, Electron

Chemicals

Antibodies, Viral Antigens, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Marston S D

Almond E J

Bishun N P

Maunsell E D

Sutton R N

References (9)

9 references, click to expand

Antibodies in human sera to soluble and viral antigens found in Burkitt lymphoma and other lymphoblastoid cell lines.
J Natl Cancer Inst. 1970 Apr;44(4):865-72 PMID: 11515054
Immunofluorescence in cells derived from Burkitt's lymphoma.
J Bacteriol. 1966 Mar;91(3):1248-56 PMID: 4160230
Culture of human leukemia cells.
Cancer. 1966 May;19(5):713-23 PMID: 5218782
Culture of normal human leukocytes.
JAMA. 1967 Feb 20;199(8):519-24 PMID: 4960081
Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis.
J Virol. 1968 Jul;2(7):663-9 PMID: 4881369
Significance of a complement-fixing antigen associated with herpes-like virus and detected in the Raji cell line.
Nature. 1969 Apr 12;222(5189):186-7 PMID: 4304930
Presence of EB virus nucleic acid homology in a "virus-free" line of Burkitt tumour cells.
Nature. 1970 Jul 18;227(5255):245-8 PMID: 4316920
Some observations on complement-fixing antibodies to the EB virus.
J Clin Pathol. 1971 Dec;24(9):801-4 PMID: 4334546
CULTIVATION IN VITRO OF HUMAN LYMPHOBLASTS FROM BURKITT'S MALIGNANT LYMPHOMA.
Lancet. 1964 Feb 1;1(7327):252-3 PMID: 14090852

Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.25.8.701

Published

1972-08-00

Pages

701-4

Language

English

Region

England

NLM ID

0376601

PMCID

PMC477481

Subset

External Links

PubMed source DOI: 10.1136/jcp.25.8.701 PMC Full Text View journal details

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A 'virus-free' cell line derived from a patient with infectious mononucleosis.

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