Individual states in the cycle of muscle contraction.
By using appropriate analogs of ATP, isometrically-held glycerol-extracted psoas fibers from rabbits are forced successively into states corresponding to molecular species in the contractile cycle. In each state measurements are made of P[unk], a fluorescence polarization parameter thought to relate to attitude of S-1 moieties of the myosin molecules. Also, the value of P[unk] is measured during active tension development. It is suggested that this value is a time-average of the P[unk] as S-1 moieties move through the various states of the cycle. Proposals are made concerning the sequence of states in the cycle.
15 references, click to expand
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Synthesis of 6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate, a sulfhydryl analog of ATP.Arch Biochem Biophys. 1970 Mar;137(1):297-8 PMID: 4244866
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Number and location of adenosine triphosphatase sites of myosin.Biochemistry. 1970 Mar 31;9(7):1528-32 PMID: 4244996
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Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P--N--P linkage.Biochemistry. 1971 Jun 22;10(13):2484-9 PMID: 4326768
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Rigor contraction and the effect of various phosphate compounds on glycerinated insect flight and vertebrate muscle.J Physiol. 1970 Jul;208(3):583-605 PMID: 5499786
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Polarization of tryptophan fluorescence from single striated muscle fibers. A molecular probe of contractile state.J Gen Physiol. 1972 Jan;59(1):103-20 PMID: 4332133
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Independent and cooperative reactions of myosin heads with F-actin in the presence of adenosine triphosphate.Biochemistry. 1971 Apr 27;10(9):1722-7 PMID: 4253014
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EPR spectral observations on the binding of ATP and F-actin to spin-labeled myosin.Biochem Biophys Res Commun. 1971 Jul 16;44(2):471-6 PMID: 4334142
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Interaction of P--N--P and P--C--P analogs of adenosine triphosphate with heavy meromyosin, myosin, and actomyosin.Biochemistry. 1971 Jun 22;10(13):2490-6 PMID: 4254149
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Polarization of tryptophan fluorescence in muscle.Biochemistry. 1969 Nov;8(11):4517-22 PMID: 5353113
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Stretch induced formation of ATP-32P in glycerinated fibres of insect flight muscle.Experientia. 1971 Jan 15;27(1):45-6 PMID: 5549237
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The binding of ADP to myosin.Biochim Biophys Acta. 1969 Jan 14;172(1):158-70 PMID: 4303201
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The conformation of myosin during the steady state of ATP hydrolysis: studies with myosin spin labeled at the S 1 thiol groups.Biochem Biophys Res Commun. 1971 Aug 20;44(4):826-30 PMID: 4331039
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Elementary processes of the magnesium ion-dependent adenosine triphosphatase activity of heavy meromyosin. A transient kinetic approach to the study of kinases and adenosine triphosphatases and a colorimetric inorganic phosphate assay in situ.Biochem J. 1972 Feb;126(3):635-44 PMID: 4263038
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Further observations on a factor (The `Marsh' factor) effecting relaxation of ATP-shortened muscle-fibre models and the effect of Ca and Mg ions upon it.J Physiol. 1953 Aug;121(2):232-54 PMID: 13085333
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ROLE OF MAGNESIUM IN CONTRACTION OF GLYCERINATED MUSCLE FIBERS.Am J Physiol. 1964 Oct;207:800-8 PMID: 14220066
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