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PMID: 4338593 Published · ppublish English Journal Article

Cytochalasin B: inhibition of glucose and glucosamine transport.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 6 ·1972-06-00 ·Pages 1430-4

Ebstensen RD, Plagemann PG

Abstract

Cytochalasin B has been shown to potently inhibit the transport of glucose, deoxyglucose, and glucosamine by Novikoff hepatoma cells in suspension culture without affecting their intracellular phosphorylation and metabolism. Deoxyglucose transport is inhibited by cytochalasin B in a simple competitive manner. Although this inhibition is not sufficient to explain the biological action of the drug on cytokinesis, it does explain earlier observations on inhibition by cytochalasin B of the incorporation of glucose and glucosamine, and probably of other extracellular precursors, into macromolecules by various types of cells.

MeSH Terms
Animals Biological Transport/drug effects Carbon Isotopes Carcinoma, Hepatocellular/metabolism Cell Line Depression, Chemical Glucosamine/metabolism Glucose/metabolism Hexoses/metabolism Kinetics Liver Neoplasms Macromolecular Substances Mycotoxins/pharmacology Neoplasms, Experimental/metabolism Oxidative Phosphorylation/drug effects Rats
Chemicals
Carbon Isotopes Hexoses Macromolecular Substances Mycotoxins Glucose Glucosamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ebstensen R D
Plagemann P G
References (18)
18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.6.1430
Published
1972-06-00
Pages
1430-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC426719
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.6.1430 PMC Full Text View journal details
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