Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection.

Journal of virology ·Vol. 9 ·No. 4 ·1972-04-00 ·Pages 714-6

Nonoyama M, Pagano JS

Abstract

Infection of Raji cells with Epstein-Barr virus (EBV) causes suppression of cellular deoxyribonucleic acid (DNA) synthesis and fragmentation of the cellular DNA. About 1,000 copies of EBV DNA of normal size (about 5 x 10(7) daltons in a single strand, as shown in an alkaline gradient) are synthesized per cell.

MeSH Terms

Burkitt Lymphoma Carbon Isotopes Cell Line/metabolism Centrifugation, Density Gradient DNA Replication DNA, Neoplasm/biosynthesis,metabolism DNA, Viral/biosynthesis Fluorescent Antibody Technique Herpesviridae/metabolism Herpesvirus 4, Human/metabolism Humans Nucleic Acid Hybridization Sucrose Thymidine/metabolism Tritium

Chemicals

Carbon Isotopes DNA, Neoplasm DNA, Viral Tritium Sucrose Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nonoyama M

Pagano J S

References (6)

6 references, click to expand

Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures.
Proc Natl Acad Sci U S A. 1969 Jul;63(3):740-7 PMID: 5259761
Differential reactivity of human serums with early antigens induced by Epstein-Barr virus.
Science. 1970 Jul 10;169(3941):188-90 PMID: 4316788
Induction of cellular DNA synthesis in human leukocytes by Epstein-Barr virus.
Nature. 1971 May 7;231(5297):46-7 PMID: 4325099
Detection of Epstein-Barr viral genome in nonproductive cells.
Nat New Biol. 1971 Sep 22;233(38):103-6 PMID: 4328798
Host cell macromolecular synthesis in cells containing EBV-induced early antigens, studied by combined immunofluorescence and radioautography.
Virology. 1971 Jul;45(1):22-9 PMID: 4329587
Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.
J Virol. 1971 Aug;8(2):125-32 PMID: 4329966

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.9.4.714-716.1972

Published

1972-04-00

Pages

714-6

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356360

Subset

External Links

PubMed source DOI: 10.1128/JVI.9.4.714-716.1972 PMC Full Text View journal details

Analysis Services

Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection.

Contact

WeChat Official Account