Inhibition of protein synthesis in L cells infected with vesicular stomatitis virus.

Journal of virology ·Vol. 9 ·No. 1 ·1972-01-00 ·Pages 85-9

Wertz GW, Youngner JS

Abstract

The inhibition of protein synthesis in L cells by vesicular stomatitis virus (VSV) requires the synthesis of new protein subsequent to virus infection. However, two mechanisms may be involved in the inhibition of cell protein synthesis by VSV: an initial, multiplicity-dependent, ultraviolet-insensitive inhibition and a progressive, ultraviolet-sensitive inhibition.

MeSH Terms

Animals Cycloheximide/pharmacology Filtration L Cells/drug effects,metabolism Leucine/metabolism Mice Protein Biosynthesis Time Factors Trichloroacetic Acid Tritium Ultraviolet Rays Vesicular stomatitis Indiana virus/radiation effects

Chemicals

Tritium Trichloroacetic Acid Cycloheximide Leucine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wertz G W

Youngner J S

References (9)

9 references, click to expand

Action of interferon: kinetics and differential effects on viral functions.
J Virol. 1970 Oct;6(4):421-9 PMID: 5497887
Fusion of vesicular stomatitis virus with the cytoplasmic membrane of L cells.
J Virol. 1969 Jun;3(6):619-22 PMID: 4307905
The mechanism of early inhibition by an RNA phage of protein and RNA synthesis in infected cells.
Virology. 1969 Mar;37(3):429-36 PMID: 4975944
Viropexis of vesicular stomatitis virus by L cells.
Virology. 1969 Feb;37(2):285-90 PMID: 4303490
MENGOVIRUS-INDUCED INHIBITION OF HOST RIBONUCLEIC ACID AND PROTEIN SYNTHESIS.
Biochim Biophys Acta. 1963 Nov 22;76:425-30 PMID: 14097404
Interferon production by inactivated Newcastle disease virus in cell cultures and in mice.
J Bacteriol. 1966 Oct;92(4):862-8 PMID: 5926753
Inhibition of cellular RNA synthesis by nonreplicating vesicular stomatitis virus.
Proc Natl Acad Sci U S A. 1965 Dec;54(6):1579-84 PMID: 4286667
Interferon production and inhibition of host synthesis in cells infected with vesicular stomatitis virus.
J Virol. 1970 Oct;6(4):476-84 PMID: 5497894
Inhibition of HeLa cell protein synthesis by the vaccinia virion.
J Virol. 1968 Oct;2(10):1028-37 PMID: 5723706

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.9.1.85-89.1972

Published

1972-01-00

Pages

85-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356265

Subset

External Links

PubMed source DOI: 10.1128/JVI.9.1.85-89.1972 PMC Full Text View journal details

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Inhibition of protein synthesis in L cells infected with vesicular stomatitis virus.

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