Inhibition of angiotensin I converting enzyme by venom peptides.

British journal of pharmacology ·Vol. 43 ·No. 1 ·1971-09-00 ·Pages 252-4

Bakhle YS

Abstract

The synthetic analogues of three naturally occurring peptides from the venom of Bothrops jararaca have been tested as inhibitors of angiotensin converting enzyme activity in two systems. They have widely differing absolute potencies but the relative potencies are similar in the two systems. The high inhibitory potency of the nonapeptide is compatible with a non-competitive type of inhibition.

MeSH Terms

Angiotensin II/antagonists & inhibitors Animals Drug Synergism Enzyme Inhibitors Guinea Pigs In Vitro Techniques Lung/enzymology Muscle Contraction/drug effects Peptides/pharmacology Perfusion Protein Conformation Structure-Activity Relationship Venoms/pharmacology

Chemicals

Enzyme Inhibitors Peptides Venoms Angiotensin II

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bakhle Y S

References (6)

6 references, click to expand

Conversion of angiotensin I to angiotensin II by cell-free extracts of dog lung.
Nature. 1968 Nov 30;220(5170):919-21 PMID: 4301850
Subcellular distribution and properties of the bradykinin inactivation system in rabbit brain homogenates.
Biochem Pharmacol. 1969 Feb;18(2):548-9 PMID: 5778163
Metabolism of the angiotensins in isolated perfused tissues.
Nature. 1969 Jun 7;222(5197):956-9 PMID: 4307046
Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme.
Nature. 1970 Jan 24;225(5230):379-80 PMID: 4312128
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.
Biochemistry. 1970 Jun 23;9(13):2583-93 PMID: 4317874
A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.
Br J Pharmacol Chemother. 1965 Feb;24:163-9 PMID: 14302350

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1971.tb07176.x

Published

1971-09-00

Pages

252-4

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1665952

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1971.tb07176.x PMC Full Text View journal details

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Inhibition of angiotensin I converting enzyme by venom peptides.

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