Nicotinamide deamidation by microorganisms in rat stomach.

Journal of bacteriology ·Vol. 108 ·No. 1 ·1971-10-00 ·Pages 191-5

Shimoyama M, Tanigawa Y, Ito T, Murashima R, Ueda I, Tomoda T

Abstract

We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis, and Lactobacillus acidophilus, listed in order of decreasing deamidase activity. Nicotinamide-7-(14)C ingested into rat stomach was rapidly deamidated to nicotinic acid. These results contribute to the accumulated evidence that microorganisms present in the pars preventricularis of rat stomach are responsible for the deamidation of nicotinamide to nicotinic acid, a known precursor of mammalian pyridine nucleotides.

MeSH Terms

Aminohydrolases/metabolism Animals Bacteriological Techniques Carbon Isotopes Chromatography, Paper Enterococcus faecalis/enzymology,isolation & purification,metabolism Escherichia coli/enzymology,isolation & purification,metabolism Flavobacterium/enzymology,isolation & purification,metabolism Gastric Mucosa/microbiology Hydrogen-Ion Concentration Lactobacillus acidophilus/enzymology,isolation & purification,metabolism Male NAD/biosynthesis Niacinamide/metabolism Nicotinic Acids/biosynthesis Rats Rats, Inbred Strains Stomach/microbiology

Chemicals

Carbon Isotopes Nicotinic Acids NAD Niacinamide Aminohydrolases

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Shimoyama M

Tanigawa Y

Ito T

Murashima R

Ueda I

Tomoda T

References (27)

27 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.108.1.191-195.1971

Published

1971-10-00

Pages

191-5

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC247050

Subset

External Links

PubMed source DOI: 10.1128/jb.108.1.191-195.1971 PMC Full Text View journal details

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Nicotinamide deamidation by microorganisms in rat stomach.

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