Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with Parkinson's disease.

Science (New York, N.Y.) ·Vol. 204 ·No. 4393 ·1979-05-11 ·Pages 624-6

Lovenberg W, Levine RA, Robinson DS, Ebert M, Williams AC, Calne DB

Abstract

A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrsopinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed.

MeSH Terms

Biopterin/analogs & derivatives,analysis,cerebrospinal fluid Homovanillic Acid/cerebrospinal fluid Humans Methods Parkinson Disease/cerebrospinal fluid Pteridines/cerebrospinal fluid

Chemicals

Pteridines Biopterin Homovanillic Acid

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Lovenberg W

Levine R A

Robinson D S

Ebert M

Williams A C

Calne D B

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.432666

Published

1979-05-11

Pages

624-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.432666 View journal details

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Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with Parkinson's disease.

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