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PMID: 4322346 Published · ppublish English Journal Article

D-Mannitol utilization in Salmonella typhimurium.

Journal of bacteriology ·Vol. 105 ·No. 1 ·1971-01-00 ·Pages 232-40

Berkowitz D

Abstract

A biochemical and genetic analysis of d-mannitol metabolism in Salmonella typhimurium indicates that d-mannitol is phosphorylated by the phosphoenolpyruvate-dependent phosphotransferase system. d-Mannitol-1-phosphate is converted to d-fructose-6-phosphate by mannitol-1-phosphate dehydrogenase. Two classes of mannitol mutants are described. Both map at about 115 min on the Salmonella chromosome. Mutants missing mannitol-1-phosphate dehydrogenase activity are mannitol sensitive; i.e., either growth is inhibited or the cells are lysed in the presence of mannitol. In a strain missing adenyl cyclase activity, the mannitol genes require exogenous cyclic adenosine-3',5'-monophosphate for expression.

MeSH Terms
Adenine Nucleotides Alcohol Oxidoreductases/metabolism Carbon Isotopes Chromosome Mapping Culture Media Cyclic AMP/metabolism
Chemicals
Adenine Nucleotides Carbon Isotopes Culture Media Cyclic AMP Alcohol Oxidoreductases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Berkowitz D
References (36)
36 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.105.1.232-240.1971
Published
1971-01-00
Pages
232-40
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC248346
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.105.1.232-240.1971 PMC Full Text View journal details
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