Specificity of the DNA product of the C-type virus RNA-dependent DNA polymerase.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 1 ·1971-01-00 ·Pages 10-2

Hatanaka M, Huebner RJ, Gilden RV

Abstract

The specificity of the DNA product of the RNA-dependent DNA polymerase found in C-type virions was analyzed by reciprocal hybridization with RNA from viruses of mouse, hamster, cat, and viper. These tests revealed a clear species specificity for the DNA product with no detectable interspecies hybridization.

MeSH Terms

Animals Cats Centrifugation, Density Gradient Cricetinae DNA Nucleotidyltransferases/metabolism DNA, Viral/analysis,biosynthesis Hybridization, Genetic Leukemia Virus, Murine/enzymology,metabolism Mice Phosphorus Isotopes RNA, Viral/metabolism Snakes Species Specificity Tritium

Chemicals

DNA, Viral Phosphorus Isotopes RNA, Viral Tritium DNA Nucleotidyltransferases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hatanaka M

Huebner R J

Gilden R V

References (13)

13 references, click to expand

Reptilian C-type virus: biophysical, biological, and immunological properties.
Virology. 1970 May;41(1):187-90 PMID: 4986313
Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus.
Proc Natl Acad Sci U S A. 1970 Feb;65(2):310-7 PMID: 4984233
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
Nature. 1970 Jun 27;226(5252):1211-3 PMID: 4316301
RNA-dependent DNA polymerase in virions of RNA tumour viruses.
Nature. 1970 Jun 27;226(5252):1209-11 PMID: 4316300
Electron microscopic observations on a "C"-type virus in cell cultures derived from a tumor-bearing viper.
J Natl Cancer Inst. 1969 Nov;43(5):1097-102 PMID: 4982059
DNA synthesis by RNA-containing tumor viruses.
Proc Natl Acad Sci U S A. 1970 Oct;67(2):1034-41 PMID: 4331715
Replication of cat leukemia virus in cell suspension cultures.
Nature. 1969 May 10;222(5193):589-90 PMID: 5818677
DNA-directed DNA polymerase activity in oncogenic RNA viruses.
Nature. 1970 Sep 5;227(5262):1029-31 PMID: 4317810
DNA polymerase activity associated with RNA tumor viruses.
Proc Natl Acad Sci U S A. 1970 Sep;67(1):143-7 PMID: 4318773
The specificity of molecular hybridization reactions.
Annu Rev Biochem. 1970;39:131-50 PMID: 4922848
Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus.
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1432-9 PMID: 4322024
Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses.
Nature. 1970 Aug 8;227(5258):563-7 PMID: 4317039
Formation of viral RNA-DNA hybrid molecules by the DNA polymerase of sarcoma-leukaemia viruses.
Nature. 1970 Sep 5;227(5262):1026-8 PMID: 5449765

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.1.10

Published

1971-01-00

Pages

10-2

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC391089

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.1.10 PMC Full Text View journal details

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Specificity of the DNA product of the C-type virus RNA-dependent DNA polymerase.

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