Electron microscopic study of the development of simian virus 40 by use of ferritin-labeled antibodies.

Journal of virology ·Vol. 1 ·No. 2 ·1967-04-00 ·Pages 384-99

Oshiro LS, Rose HM, Morgan C, Hsu KC

Abstract

An electron microscopic study of simian virus 40 has revealed a number of structural changes that are related to the development of the virus. The presence of viral antigens in both the nucleus and the cytoplasm has been demonstrated by means of ferritin-labeled antibodies. Although cytoplasmic virions are readily tagged, the lack of tagging of nuclear particles presents a perplexing problem. Presumably, the virus, after release from the nucleus, acquires a new antigenic reactivity in the cytoplasm.

MeSH Terms

Animals Antibodies Cell Line Ferritins Haplorhini Kidney Microscopy, Electron Simian virus 40/growth & development

Chemicals

Antibodies Ferritins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Oshiro L S

Rose H M

Morgan C

Hsu K C

References (15)

15 references, click to expand

An electron microscope study of the early association between two mammalian viruses and their hosts.
J Cell Biol. 1962 May;13:303-22 PMID: 13883196
Papova virus group.
Science. 1962 Mar 30;135(3509):1128-30 PMID: 14472429
Biophysical studies on the nature of the simian papova virus particle (vacuolating SV40 virus).
Virology. 1963 Mar;19:359-66 PMID: 13934172
THE PURIFICATION OF SIMIAN VIRUS 40.
Virology. 1964 Nov;24:381-7 PMID: 14227039
An electron microscope study of polyoma virus in hamster kidney.
J Biophys Biochem Cytol. 1960 Jul;7:753-60 PMID: 14403476
The vacuolating virus of monkeys. II. Virus morphology and intranuclear distribution with some histochemical observations.
J Exp Med. 1961 Dec 1;114:987-96 PMID: 13897378
The influence of p-fluoro-phenylalanine, puromycin, and actinomycin on the development of simian papovavirus (SV40).
Exp Mol Pathol. 1966 Jun;5(3):245-62 PMID: 4288068
[Electron microscopic demonstration of a virus in cells infected in vitro by the polyoma agent].
C R Hebd Seances Acad Sci. 1959 Jul 20;249:483-5 PMID: 13799751
Intracellular and extracellular particles in tissue cultures inoculated with parotid-tumor agent (polyoma virus).
J Natl Cancer Inst. 1959 Nov;23:1123-35 PMID: 13796411
IMMUNOCHEMICAL STAINING FOR ELECTRON MICROSCOPY.
J Histochem Cytochem. 1964 Feb;12:131-6 PMID: 14192069
Preparation of an electron-dense antibody conjugate.
Nature. 1959 May 30;183(4674):1523-4 PMID: 13666799
An electron microscope study of the development of SV40 virus.
J Cell Biol. 1963 May;17:423-41 PMID: 13963379
Ultrastructural cytochemistry applied to the study of virus infection.
Cold Spring Harb Symp Quant Biol. 1962;27:67-82 PMID: 13971077
Immunofluorescent, cytochemical, and microcytological studies on the growth of the simian vacuolating virus (SV-40) in tissue culture.
Exp Mol Pathol. 1962 Oct;1:397-416 PMID: 13934174
Acridine orange staining of purified polyoma virus.
Proc Soc Exp Biol Med. 1961 Oct;108:103-5 PMID: 14471761

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.1.2.384-399.1967

Published

1967-04-00

Pages

384-99

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375237

Subset

External Links

PubMed source DOI: 10.1128/JVI.1.2.384-399.1967 PMC Full Text View journal details

Analysis Services

Electron microscopic study of the development of simian virus 40 by use of ferritin-labeled antibodies.

Contact

WeChat Official Account