Neurally mediated increase in dopamine-beta-hydroxylase activity.
The development of a sensitive and specific enzymatic assay for dopamine-beta-hydroxylase has enabled us to measure the activity of this enzyme in several tissues where it has previously been measured. The administration of reserpine leads to an increase in dopamine-beta-hydroxylase activity in the rat adrenal, heart, salivary gland, and in sympathetic ganglia. The increase in the heart is preceded by a small but significant fall. We have confirmed the increase in tyrosine hydroxylase which follows the administration of reserpine and have found that the activity of phenylethanolamine-N-methyltransferase also increases after administration of this drug. The activities of two enzymes not involved in the synthesis of catecholamines, monoamine oxidase and lactate dehydrogenase, are not affected by reserpine treatment. The rise of dopamine-beta-hydroxylase activity in the sympathetic ganglia is blocked by surgical decentralization.
17 references, click to expand
-
Increased synthesis and release of noradrenaline and dopamine during nerve stimulation.Life Sci. 1967 Jan 1;6(1):97-104 PMID: 6030561
-
A new class of tyrosine hydroxylase inhibitors and a simple assay of inhibition in vivo.Biochem Pharmacol. 1967 Jul 7;16(7):1313-21 PMID: 6053599
-
Secretion from the adrenal medulla: biochemical evidence for exocytosis.Br J Pharmacol Chemother. 1967 Sep;31(1):94-104 PMID: 6058830
-
The effect of nerve stimulation on the synthesis and metabolism of norepinephrine in the isolated guinea-pig hypogastric nerve-vas deferens preparation.J Pharmacol Exp Ther. 1968 Mar;160(1):61-71 PMID: 5644214
-
Enzymatic conversion of norepinephrine to epinephrine by the brain.J Pharmacol Exp Ther. 1969 Feb;165(2):190-5 PMID: 5763055
-
The distribution of the glucosyl substituents along the chain of the teichoic acid in walls of Lactobacillus buchneri N.C.I.B. 8007.Biochem J. 1969 Jan;111(2):245-6 PMID: 5763791
-
Enzymatic synthesis of adrenaline in mammalian brain.Nature. 1969 Jan 25;221(5178):368-9 PMID: 5764440
-
Increase in tyrosine hydroxylase activity after reserpine administration.J Pharmacol Exp Ther. 1969 Sep;169(1):74-9 PMID: 5804613
-
Inhibition of trans-synaptically increased tyrosine hydroxylase activity by cycloheximide and actinomycin D.Mol Pharmacol. 1969 Sep;5(5):463-9 PMID: 4309928
-
Trans-synaptic induction of adrenal tyrosine hydroxylase.J Pharmacol Exp Ther. 1969 Oct;169(2):249-54 PMID: 4309998
-
An enzymatic assay for octopamine and other beta-hydroxylated phenylethylamines.J Pharmacol Exp Ther. 1969 Dec;170(2):253-61 PMID: 4901590
-
Mechanism of secretion from the adrenal medulla. 3. Studies of dopamine beta-hydroxylase as a marker for catecholamine storage vesicle membranes in rabbit adrenal glands.Mol Pharmacol. 1969 Jan;5(1):60-8 PMID: 5373888
-
Protein measurement with the Folin phenol reagent.J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
-
A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.Biochem Pharmacol. 1963 Dec;12:1439-41 PMID: 14096433
-
PROPERTIES OF NOREPINEPHRINE STORAGE PARTICLES OF THE RAT HEART.J Pharmacol Exp Ther. 1963 Dec;142:299-305 PMID: 14098325
-
Purification and properties of phenylethanolamine-N-methyl transferase.J Biol Chem. 1962 May;237:1657-60 PMID: 13863458
-
DOPAMINE-BETA-HYDROXYLASE.Pharmacol Rev. 1965 Jun;17:71-100 PMID: 14294032
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