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PMID: 4317915 Published · ppublish English Journal Article

Membrane structure: lipid-protein interactions in microsomal membranes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 2 ·1970-06-00 ·Pages 433-40

Trump BF, Duttera SM, Byrne WL, Arstila AU

Abstract

The relationships of phospholipid to membrane structure and function were examined in hepatic microsomes. Findings indicate that normal microsomal membrane structure is dependent on lipid-protein interactions and that it correlates closely with glucose-6-phosphatase activity. Modification of most phospholipid with phospholipase-C is associated with widening of the membrane which can be reversed following readdition of phospholipid.

MeSH Terms
Animals Densitometry Glucose-6-Phosphatase/metabolism Male Membranes/drug effects,metabolism,physiology Microscopy, Electron Microsomes, Liver/enzymology,metabolism,physiology Phospholipases/pharmacology Phospholipids/metabolism Rats
Chemicals
Phospholipids Phospholipases Glucose-6-Phosphatase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Trump B F
Duttera S M
Byrne W L
Arstila A U
References (12)
12 references, click to expand
  1. Protein conformations in cellular membranes.
    Proc Natl Acad Sci U S A. 1966 Nov;56(5):1552-9 PMID: 5230314
  2. Structure of biological membranes.
    Science. 1966 Sep 23;153(3743):1491-8 PMID: 5331262
  3. Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration.
    Am J Pathol. 1968 Nov;53(5):687-733 PMID: 4300890
  4. Lipid protein interactions in cellular membranes.
    Fed Proc. 1968 Nov-Dec;27(6):1263-8 PMID: 5725216
  5. A requirement for phospholipids by the microsomal reduced diphosphopyridine nucleotide-cytochrome c reductase.
    J Biol Chem. 1967 Nov 25;242(22):5267-73 PMID: 4294332
  6. Current concepts of membrane structure and function.
    Fed Proc. 1969 Jan-Feb;28(1):6-11 PMID: 4884665
  7. Fine structure of lipid-depleted mitochondria.
    J Cell Biol. 1967 Jan;32(1):193-208 PMID: 10976210
  8. Structure of membranes: reaction of red blood cell membranes with phospholipase C.
    Science. 1968 Feb 16;159(3816):738-9 PMID: 17795071
  9. Studies on the phospholipid requirement of glucose 6-phosphatase.
    J Biol Chem. 1968 May 10;243(9):2216-28 PMID: 4296834
  10. A simple method for the isolation and purification of total lipides from animal tissues.
    J Biol Chem. 1957 May;226(1):497-509 PMID: 13428781
  11. The action of phospholipase C on muscle microsomes: a correlation of electron microscope and biochemical data.
    Biochim Biophys Acta. 1965 Jun 1;98(3):547-53 PMID: 5837455
  12. On the cooperativity of biological membranes.
    Proc Natl Acad Sci U S A. 1967 Feb;57(2):335-41 PMID: 16591474
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.66.2.433
Published
1970-06-00
Pages
433-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC283063
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.66.2.433 PMC Full Text View journal details
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