Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.

Journal of virology ·Vol. 1 ·No. 6 ·1967-12-00 ·Pages 1150-7

Knudson AG, Brodetsky AM, Baluda MA

Abstract

Avian myeloblastosis virus cannot initiate its reproduction in the presence of amethopterin or fluorodeoxyuridine. This inhibition is reversed by thymidine. Addition of either inhibitor after virus production has started does not inhibit further virus synthesis. In presence of either inhibitor, deoxyribonucleic acid synthesis is inhibited by over 90%, but ribonucleic acid synthesis is not affected. Cells resume their normal growth rate 24 hr after removal of either inhibitor.

MeSH Terms

Animals Antiviral Agents/pharmacology Avian Leukosis Virus/drug effects,growth & development Cell Division/drug effects Chick Embryo Culture Techniques DNA, Viral/biosynthesis Fibroblasts Floxuridine/pharmacology Methotrexate/pharmacology RNA, Viral/biosynthesis Thymidine/pharmacology Tritium Uridine Virus Replication/drug effects

Chemicals

Antiviral Agents DNA, Viral RNA, Viral Floxuridine Tritium Thymidine Uridine Methotrexate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Knudson A G

Brodetsky A M

Baluda M A

References (14)

14 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.1.6.1150-1157.1967

Published

1967-12-00

Pages

1150-7

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375403

Subset

External Links

PubMed source DOI: 10.1128/JVI.1.6.1150-1157.1967 PMC Full Text View journal details

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Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.

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