Proteins specified by herpes simplex virus. 3. Viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 65 ·No. 4 ·1970-04-00 ·Pages 865-71

Keller JM, Spear PG, Roizman B

Abstract

We examined the electrophoretic properties of the proteins and glycoproteins in the smooth membranes and virions purified from cells infected with herpes simplex virus strains differing with respect to their effects on the interaction of cells among themselves. The data show the following: (1) The glycoproteins in virions and binding to membranes share common features but vary quantitatively and qualitatively depending on the virus strain. (2) The binding to smooth membranes is ordered and not random. (3) Differences in the glycosylation of membrane proteins in African green monkey (VERO) and human (HEp-2) cells indicate that glycosylation is at least in part determined by the host.

MeSH Terms

Animals Carbon Isotopes Carcinoma Cell Line Cell Membrane/metabolism Cytopathogenic Effect, Viral Electrophoresis, Disc Glucosamine/metabolism Glycoproteins/biosynthesis Haplorhini Humans Isoleucine/metabolism Kidney Laryngeal Neoplasms Leucine/metabolism Simplexvirus/metabolism,pathogenicity Tritium Valine/metabolism Viral Proteins/analysis,biosynthesis

Chemicals

Carbon Isotopes Glycoproteins Viral Proteins Isoleucine Tritium Leucine Valine Glucosamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Keller J M

Spear P G

Roizman B

References (24)

24 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.65.4.865

Published

1970-04-00

Pages

865-71

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC282996

Subset

External Links

PubMed source DOI: 10.1073/pnas.65.4.865 PMC Full Text View journal details

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Proteins specified by herpes simplex virus. 3. Viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins.

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