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PMID: 4313191 Published · ppublish English Journal Article

Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 65 ·No. 1 ·1970-01-00 ·Pages 104-9

Friedman RM, Pastan I

Abstract

2-mercapto-1(beta-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.

MeSH Terms
Animals Benzimidazoles/pharmacology Chickens Depression, Chemical Fibroblasts/drug effects,metabolism Interferons/antagonists & inhibitors Leucine/metabolism Phosphates/metabolism Phospholipids/biosynthesis Phosphorus Isotopes Protein Biosynthesis RNA/biosynthesis Sulfhydryl Compounds/pharmacology Tritium Vesicular stomatitis Indiana virus
Chemicals
Benzimidazoles Phosphates Phospholipids Phosphorus Isotopes Sulfhydryl Compounds Tritium RNA Interferons Leucine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Friedman R M
Pastan I
References (10)
10 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.65.1.104
Published
1970-01-00
Pages
104-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286197
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.65.1.104 PMC Full Text View journal details
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