Human granulocyte collagenase.

Science (New York, N.Y.) ·Vol. 159 ·No. 3822 ·1968-03-29 ·Pages 1483-5

Lazarus GS, Brown RS, Daniels JR, Fullmer HM

Abstract

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

MeSH Terms

Acrylic Resins Arthus Reaction Carbon Isotopes Collagen/metabolism Cytoplasmic Granules/enzymology Electrophoresis Gels Humans Hydrogen-Ion Concentration Inflammation Leukocytes/cytology,enzymology Lymphocytes/enzymology Microbial Collagenase/blood Neutrophils/enzymology Viscosity

Chemicals

Acrylic Resins Carbon Isotopes Gels Collagen Microbial Collagenase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lazarus G S

Brown R S

Daniels J R

Fullmer H M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.159.3822.1483

Published

1968-03-29

Pages

1483-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.159.3822.1483 View journal details

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Human granulocyte collagenase.

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