Inhibition of coronavirus 229E replication by actinomycin D.

Journal of virology ·Vol. 29 ·No. 1 ·1979-01-00 ·Pages 401-4

Kennedy DA, Johnson-Lussenburg CM

Abstract

The yields of human coronavirus 229E grown in L132 cells were markedly inhibited by actinomycin D, the 50% inhibitory dose being 0.1 micron/ml. Inhibition was maximal during the early phase of virus replication, did not appear to involve viral RNA synthesis per se, and was shown to be dependent on the input multiplicity of infection.

MeSH Terms

Cell Line Coronaviridae/drug effects,growth & development Dactinomycin/pharmacology Dose-Response Relationship, Drug Humans RNA/biosynthesis RNA, Viral/biosynthesis Time Factors

Chemicals

RNA, Viral Dactinomycin RNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kennedy D A

Johnson-Lussenburg C M

References (11)

11 references, click to expand

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Arch Gesamte Virusforsch. 1970;31(3):293-302 PMID: 4099196
The effect of 5-bromodoxyuridine and actinomycin D on the multiplication of transmissible gastroenteritis virus.
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Ribonucleic acid synthesis in porcine cell cultures infected with transmissible gastroenteritis virus.
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.29.1.401-404.1979

Published

1979-01-00

Pages

401-4

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC353142

Subset

External Links

PubMed source DOI: 10.1128/JVI.29.1.401-404.1979 PMC Full Text View journal details

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Inhibition of coronavirus 229E replication by actinomycin D.

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