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PMID: 430594 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Influenza B virus genome: assignment of viral polypeptides to RNA segments.

Journal of virology ·Vol. 29 ·No. 1 ·1979-01-00 ·Pages 361-73

Racaniello VR, Palese P

Abstract

It was shown that all eight RNA segments of influenza B viruses are most likely monocistronic and code for eight virus-specific polypeptides. A genetic map of the influenza B virus genome was established, and six polypeptides (P1 protein, nucleoprotein, hemagglutinin, neuraminidase, M protein, and nonstructural protein) were unambiguously assigned to specific RNA segments. Molecular weight estimates of the eight individual genes are obtained by using the glyoxal method. These results suggest that each influenza B virus RNA segment has a greater molecular weight than the influenza A virus RNA segment which codes for the analogous gene product.

MeSH Terms
Genes, Viral Hemagglutinins, Viral Influenza A virus/genetics Molecular Weight Neuraminidase/biosynthesis Nucleoproteins/biosynthesis Orthomyxoviridae/genetics RNA, Viral/genetics Viral Proteins/biosynthesis
Chemicals
Hemagglutinins, Viral Nucleoproteins RNA, Viral Viral Proteins Neuraminidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Racaniello V R
Palese P
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33 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.29.1.361-373.1979
Published
1979-01-00
Pages
361-73
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353132
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.29.1.361-373.1979 PMC Full Text View journal details
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