Fusidic acid: inhibition of factor T2 in reticulocyte protein synthesis.

Science (New York, N.Y.) ·Vol. 164 ·No. 3875 ·1969-04-04 ·Pages 71-2

Malkin M, Lipmann F

Abstract

The steroid antibiotic fusidic acid inhibits reticulocyte protein synthesis. This inhibition appears to be due to interference with the activity of the T(2) supernatant fraction, and strengthens the proposition that T(2) is functionally analogous to the G-factor of bacterial protein synthesis, which is also specifically inhibited by this antibiotic.

MeSH Terms

Adenosine Triphosphate/metabolism Animals Bacterial Proteins/biosynthesis Blood Proteins/biosynthesis Cell-Free System Depression, Chemical Escherichia coli/metabolism Fusidic Acid/pharmacology Guanine Nucleotides/metabolism Mammals Peptides/metabolism Phenylalanine/metabolism Phosphoric Monoester Hydrolases/metabolism RNA, Transfer/metabolism Reticulocytes/cytology,drug effects,metabolism Ribosomes/metabolism Tritium

Chemicals

Bacterial Proteins Blood Proteins Guanine Nucleotides Peptides Tritium Phenylalanine Fusidic Acid Adenosine Triphosphate RNA, Transfer Phosphoric Monoester Hydrolases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Malkin M

Lipmann F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.164.3875.71

Published

1969-04-04

Pages

71-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.164.3875.71 View journal details

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Fusidic acid: inhibition of factor T2 in reticulocyte protein synthesis.

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