The effect of local blockage of motor nerve terminals.

The Journal of physiology ·Vol. 199 ·No. 3 ·1968-12-00 ·Pages 729-41

Katz B, Miledi R

Abstract

1. Electrophoretic application of tetrodotoxin (TTX) was used to study the effect of localized blockage of impulses in motor nerve terminals.2. Under suitable conditions it can be shown that local production of end-plate potentials ceases distal to the site of TTX application, while it continues without diminution at proximal sites of the same terminal arborization.3. It is concluded that electrotonic spread of an action potential wave along a motor nerve terminal is insufficient to elicit transmitter release. Active propagation in the terminals is an essential requirement for neuromuscular transmission.

MeSH Terms

Action Potentials Animals Anura Axons/physiology Membrane Potentials/drug effects Motor Neurons/physiology Nerve Endings/physiology Neuromuscular Junction/drug effects Synaptic Transmission Tetrodotoxin/pharmacology

Chemicals

Tetrodotoxin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Katz B

Miledi R

References (13)

13 references, click to expand

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Potential changes recorded from the frog motor nerve terminal during its activation.
Pflugers Arch Gesamte Physiol Menschen Tiere. 1966;287(1):56-80 PMID: 5233552
Localized blockage of nerve impulses at the myoneural junction.
J Physiol. 1968 Jul;197(1):7P PMID: 5675095
An analysis of the end-plate potential recorded with an intracellular electrode.
J Physiol. 1951 Nov 28;115(3):320-70 PMID: 14898516
On the localization of acetylcholine receptors.
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An electrophysiological investigation of mammalian motor nerve terminals.
J Physiol. 1963 Apr;166:145-67 PMID: 13955375
A STUDY OF SPONTANEOUS MINIATURE POTENTIALS IN SPINAL MOTONEURONES.
J Physiol. 1963 Sep;168:389-422 PMID: 14062684
LINEAR ELECTRICAL PROPERTIES OF STRIATED MUSCLE FIBRES OBSERVED WITH INTRACELLULAR ELECTRODES.
Proc R Soc Lond B Biol Sci. 1964 Apr 14;160:69-123 PMID: 14142170
PROPAGATION OF ELECTRIC ACTIVITY IN MOTOR NERVE TERMINALS.
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:453-82 PMID: 14278408
THE MEASUREMENT OF SYNAPTIC DELAY, AND THE TIME COURSE OF ACETYLCHOLINE RELEASE AT THE NEUROMUSCULAR JUNCTION.
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:483-95 PMID: 14278409
THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS.
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496-503 PMID: 14278410
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Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1968.sp008675

Published

1968-12-00

Pages

729-41

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1365367

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1968.sp008675 PMC Full Text View journal details

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The effect of local blockage of motor nerve terminals.

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