Abstract
Clostridium perfringens type A suspended in fresh medium was injected into ligated intestinal loops of lambs. Within 7 hr after inoculation, the fluid volume of the loops increased up to seven times. No significant accumulation of fluid occurred in loops receiving grown culture, culture supernatant fluid, or medium alone. alpha-Antitoxin injected along with C. perfringens in fresh medium into intestinal loops did not prevent the accumulation of fluid. It is concluded that alpha-toxin plays no major role in C. perfringens type A enteritis.
MeSH Terms
Animals
Antitoxins/therapeutic use
Clostridium Infections
Clostridium perfringens
Enteritis/chemically induced,etiology,prevention & control
Intestine, Small
Sheep
Toxins, Biological
Chemicals
Antitoxins
Toxins, Biological
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hauschild A H
Niilo L
Dorward W J
References (15)
15 references, click to expand
-
Pathogenesis of Escherichia coli enteritis in the ligated rabbit gut.
Isr J Med Sci. 1967 May-Jun;3(3):445-52
PMID: 4951242
-
Experimental enteritis with food poisoning and classical strains of Clostridium perfringens type A in lambs.
J Infect Dis. 1967 Dec;117(5):379-86
PMID: 4294920
-
Clostridium welchii food poisoning.
J Hyg (Lond). 1953 Mar;51(1):75-101
PMID: 13044934
-
Mice and monkeys as assay animals for Clostridium perfringens food poisoning.
Appl Microbiol. 1966 Jul;14(4):479-85
PMID: 4288826
-
The nature of a neutralising substance for Clostridium welchii alpha-toxin in faeces.
J Pathol Bacteriol. 1959 Jul;78:17-28
PMID: 13828561
-
Lamb losses associated with Clostridium perfringens type A.
J Am Vet Med Assoc. 1958 Aug 15;133(4):219-21
PMID: 13575288
-
Phospholipase C-producing bacteria and food poisoning. An experimental study on Clostridium perfringens and Bacillus cereus.
Acta Pathol Microbiol Scand Suppl. 1962;Suppl 160:1-88
PMID: 13939299
-
The biochemistry of the gas gangrene toxins: Estimation of the alpha toxin of Cl. welchii, type A.
Biochem J. 1941 Nov;35(10-11):1246-56
PMID: 16747410
-
Lecithinase-producing bacteria and food poisoning.
Acta Pathol Microbiol Scand Suppl. 1961;51(Suppl 144):297-8
PMID: 13729968
-
Experimental food-poisoning by Clostridium welchii.
Lancet. 1957 Jul 13;273(6985):71-4
PMID: 13450331
-
Characterization of the Phospholipases of Bacillus cereus and Their Effects on Erythrocytes, Bone, and Kidney Cells.
J Bacteriol. 1965 Jul;90(1):69-81
PMID: 16562045
-
An experimental study of the mechanism of action of Vibriod cholerae on the intestinal mucous membrane.
J Pathol Bacteriol. 1953 Oct;66(2):559-62
PMID: 13118463
-
Experimental gas gangrene with food-poisoning Clostridium perfringens type A.
Can J Microbiol. 1968 Jun;14(6):705-9
PMID: 4298928
-
EFFECT OF PH ON TOXINOGENESIS BY CLOSTRIDIUM PERFRINGENS TYPE C.
Can J Microbiol. 1964 Jun;10:329-44
PMID: 14187001
-
Rabbit ileal loop response to strains of Clostridium perfringens.
J Bacteriol. 1968 May;95(5):1560-6
PMID: 4297020