Virus-directed protein synthesis in different animal and human cells.

Science (New York, N.Y.) ·Vol. 160 ·No. 3834 ·1968-06-21 ·Pages 1346-8

Holland JJ

Abstract

The relative proportions of viral gene products (viral proteins) that are synthesized in different types of animal cells infected with the same RNA virus inoculum were compared. The relative rates of synthesis of the various virus proteins late in infection were remarkably constant regardless of cell type infected. This was true in cell lines that produced only small amounts of virus and virus proteins, as well as in those that gave large yields of viruses and virus proteins.

MeSH Terms

Amnion/microbiology Animals Carbon Isotopes Culture Techniques Cytopathogenic Effect, Viral Electrophoresis, Disc Encephalomyocarditis virus/metabolism Fibroblasts/microbiology HeLa Cells/microbiology Humans Mice Phenylalanine/metabolism Picornaviridae/metabolism Poliovirus/metabolism RNA Viruses/metabolism RNA, Viral/metabolism Tritium Tyrosine/metabolism Valine/metabolism Viral Proteins/analysis,biosynthesis

Chemicals

Carbon Isotopes RNA, Viral Viral Proteins Tritium Tyrosine Phenylalanine Valine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Holland J J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.160.3834.1346

Published

1968-06-21

Pages

1346-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.160.3834.1346 View journal details

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