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PMID: 4279905 Published · ppublish English Journal Article

Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae.

Journal of bacteriology ·Vol. 120 ·No. 3 ·1974-12-00 ·Pages 1284-92

Sarubbi FA, Blackman E, Sparling PF

Abstract

Loci for resistance to several antibiotics in laboratory-derived strains of Neisseria gonorrhoeae were mapped by genetic transformation. Genes for high-level resistance to streptomycin (str) and spectinomycin (spc) and for low-level resistance to tetracycline (tet) and chloramphenicol (chl) were linked. Also, a locus for high-level resistance to rifampin (rif) was linked to str and tet. The apparent order was rif... str... tet... chl... spc. Loci for resistance to other antibiotics (penicillin, erythromycin) were transferred independently of each other and were not linked to the cluster around str. Similar linkage relationships were found with str, tet, chl, and spc loci obtained from naturally occurring (clinical) isolates of N. gonorrhoeae.

MeSH Terms
Anti-Bacterial Agents/pharmacology Chloramphenicol/pharmacology Chromosome Mapping Erythromycin/pharmacology Genetic Linkage Mutation Neisseria gonorrhoeae/drug effects Penicillin Resistance Penicillins/pharmacology Phenotype Recombination, Genetic Rifampin/pharmacology Spectinomycin/pharmacology Streptomycin/pharmacology Tetracycline/pharmacology Transformation, Genetic
Chemicals
Anti-Bacterial Agents Penicillins Erythromycin Chloramphenicol Spectinomycin Tetracycline Rifampin Streptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sarubbi F A
Blackman E
Sparling P F
References (16)
16 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.120.3.1284-1292.1974
Published
1974-12-00
Pages
1284-92
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC245913
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.120.3.1284-1292.1974 PMC Full Text View journal details
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