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PMID: 4271339 Published · ppublish English Journal Article

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

The American journal of pathology ·Vol. 73 ·No. 2 ·1973-11-00 ·Pages 457-76

Burger PC, Vogel FS

Abstract

Senile plaques, neurofibrillary change and granulovacuolar degeneration characterize Alzheimer's disease (presenile dementia) and senile dementia and are also seen in the aged human brain. The development of these lesions was studied in 13 patients with Down's syndrome, ages 12 to 65, with the purpose of defining similarities and dissimilarities, if any, between their morphologies in these four conditions. Evaluation by light and, when applied, electron microscopy established apparent identities. The findings suggest that Down's syndrome, with its partially characterized genotypic and phenotypic abnormalities, is an appropriate model for the study of the pathogenesis of these lesions.

MeSH Terms
Adolescent Adult Aged Autopsy Brain/pathology Brain Chemistry Child Child, Preschool Dementia/complications,pathology Down Syndrome/complications,enzymology,immunology,metabolism,pathology Female Genotype Hippocampus/pathology Homovanillic Acid/metabolism Humans Hydroxyindoleacetic Acid/metabolism Immunoglobulins/metabolism Male Microscopy, Electron Middle Aged Neurofibrils Neurons Phenotype
Chemicals
Immunoglobulins Hydroxyindoleacetic Acid Homovanillic Acid
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Burger P C
Vogel F S
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25 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1973-11-00
Pages
457-76
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1904076
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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