Home LiteratureArticle Details
PMID: 4269843 Published · ppublish English Journal Article Review

The relationship of the (Na + + K + )-activated enzyme system to transport of sodium and potassium across the cell membrane..

Journal of bioenergetics ·Vol. 4 ·No. 1 ·1973-01-00 ·Pages 1-30

Skou JC

Abstract

暂无摘要

MeSH Terms
Adenosine Triphosphatases/metabolism Adenosine Triphosphate/metabolism Biological Transport Cell Membrane/enzymology Enzyme Activation Lipid Metabolism Magnesium/metabolism Mathematics Models, Biological Multienzyme Complexes/metabolism Potassium/metabolism Protein Binding Sodium/metabolism
Chemicals
Multienzyme Complexes Adenosine Triphosphate Sodium Adenosine Triphosphatases Magnesium Potassium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Skou J C
References (97)
97 references, click to expand
  1. Ion transport and phosphorroteins of human red cells.
    Biochim Biophys Acta. 1962 Dec 17;65:472-80 PMID: 13957950
  2. (K+)-dependent acyl phosphatase as part of the (na+ + K+)-dependent ATPase of cell membranes.
    Biochim Biophys Acta. 1966 Apr 12;118(1):116-23 PMID: 4288974
  3. The involvement of phosphatidylserine in adenosine triphosphatase activity of the sodium pump.
    J Physiol. 1970 Apr;207(2):303-28 PMID: 4250771
  4. Sodium-potassium-activated adenosine triphosphatase of Electrophorus electric organ. II. Effects of N-ethylmaleimide and other sulfhydryl reagents.
    J Biol Chem. 1966 Apr 25;241(8):1890-5 PMID: 4223457
  5. [ROLE OF PHOSPHATIDES IN ADENOSINE TRIPHOSPHATASE SENSITIVE TO OUABAIN LOCALIZED IN ERYTHROCYTE MEMBRANES].
    J Biochem. 1964 Oct;56:377-8 PMID: 14240993
  6. Simple allosteric model for membrane pumps.
    Nature. 1966 Aug 27;211(5052):969-70 PMID: 5968307
  7. Membrane adenosine triphosphatase and cation transport.
    Br Med Bull. 1968 May;24(2):165-9 PMID: 4231272
  8. Comparison of sources of a phosphorylated intermediate in transport ATPase.
    Biochim Biophys Acta. 1968 Jan 3;150(1):41-6 PMID: 4230616
  9. The stoicheiometry of the sodium pump.
    J Physiol. 1967 Sep;192(1):217-35 PMID: 4228075
  10. Potassium-activated phosphatase from human red blood cells : The Effects of Adenosine Triphosphate.
    J Membr Biol. 1970 Dec;3(1):26-42 PMID: 24174182
  11. Post-tetanic hyperpolarization and electrogenic Na pump in stretch receptor neurone of crayfish.
    J Physiol. 1966 Nov;187(1):105-27 PMID: 4226418
  12. Studies on the Na ion and K ion activated ATP hydrolysing enzyme system. The role of SH groups.
    Biochem Biophys Res Commun. 1963 Jan 18;10:79-84 PMID: 13989106
  13. Lipoprotein nature of red cell adenosine triphosphatase.
    Nature. 1962 Nov 17;196:677 PMID: 13976722
  14. Highly specific sodium-potassium-activated adenosine triphosphatase from various tissues of rabbit.
    Biochem Biophys Res Commun. 1965 Jun 9;19(6):755-8 PMID: 4221031
  15. On the reaction sequence of the K + -dependent acetyl phosphatase activity of the Na + pump.
    Biochim Biophys Acta. 1971 Aug 13;241(2):650-60 PMID: 4334150
  16. The ouabain-sensitive fluxes of sodium and potassium in squid giant axons.
    J Physiol. 1969 Feb;200(2):459-96 PMID: 5812424
  17. Electron microscopy of a microsomal fraction ritch in (Na++K+)-ATPase and isolated from kidney cortex. Structural changes accompanying freeze- and DOC-activation and identification of main components.
    Exp Cell Res. 1971 Oct;68(2):356-71 PMID: 4108041
  18. The coupling of downhill ion movements associated with reversal of the sodium pump in human red cells.
    J Physiol. 1970 Apr;207(2):291-301 PMID: 5499021
  19. Studies on plasma membranes. V. On the lipid dependence of some phosphohydrolases of isolated rat-liver plasma membranes.
    Biochim Biophys Acta. 1968 Apr 29;150(3):341-53 PMID: 4297058
  20. Nucleotide requirements for sodium-sodium exchange catalysed by the sodium pump in human red cells.
    J Physiol. 1971 Oct;218(1):239-56 PMID: 4257032
  21. Active sodium and potassium transport in high potassium and low potassium sheep red cells.
    J Gen Physiol. 1971 Oct;58(4):438-66 PMID: 5112660
  22. The sensitivity of the sodium pump to external sodium.
    J Physiol. 1967 Sep;192(1):175-88 PMID: 6051802
  23. Coupling and selectivity of sodium and potassium transport in squid giant axons.
    J Gen Physiol. 1968 May 1;51(5):152-61 PMID: 19873583
  24. Sodium-potassium-activated adenosine triphosphatase. IV. Characterization of the phosphoprotein formed from orthophosphate in the presence of ouabain.
    J Biol Chem. 1969 Jun 25;244(12):3264-9 PMID: 4240028
  25. The incorporation of inorganic phosphate into adenosine triphosphate by reversal of the sodium pump.
    J Physiol. 1967 Sep;192(1):237-56 PMID: 4228076
  26. OLIGOMYCIN AND ACTIVE TRANSPORT REACTIONS IN CELL MEMBRANES.
    Nature. 1964 Aug 15;203:720-4 PMID: 14207264
  27. The asymmetrical stimulation of a membrane adenosine triphosphatase in relation to active cation transport.
    Biochem J. 1962 Jul;84:110-8 PMID: 14006660
  28. The behaviour of the sodium pump in red cells in the absence of external potassium.
    J Physiol. 1967 Sep;192(1):159-74 PMID: 6051801
  29. A comparison of microsomal (Na+ + K+)-ATPase with K+-acetylphosphatase.
    Biochim Biophys Acta. 1967 Jul 11;139(2):450-9 PMID: 4291926
  30. Sodium-potassium-activated adenosine triphosphatase of Electrophorus electric organ. V. Phosphorylation by adenosine triphosphate-32P.
    J Biol Chem. 1968 Apr 25;243(8):1993-2002 PMID: 4230834
  31. Sodium-activated adenosine triphosphatase activity of the erythrocyte membrane.
    J Biol Chem. 1970 Jan 25;245(2):270-5 PMID: 4243950
  32. Phosphatidyl serine requirement of (Na+-K+)-activated adenosine triphosphatase from rat kidney and brain.
    Biochim Biophys Acta. 1967 Apr 4;137(2):406-8 PMID: 4293105
  33. Comparative studies on K -p-nitrophenylphosphatase, K -acylphosphatase and (Na + K)adenosinetriphosphatase in synaptosomes of rat brain.
    Hoppe Seylers Z Physiol Chem. 1968 Jul;349(7):909-19 PMID: 4302251
  34. Studies on the partial reactions catalyzed by the (Na+ + K+)-activated ATPase. I. Effects of simple anions and nucleoside triphosphates on the alkali-cation specificity of the p-nitrophenylphosphatase.
    Biochim Biophys Acta. 1971 Jan 5;225(1):11-9 PMID: 4250835
  35. Purification of the sodium- and potassium-dependent adenosine triphosphatase from canine renal medulla.
    J Biol Chem. 1971 Jul 10;246(13):4157-65 PMID: 4253595
  36. Sodium-potassium-activated adenosine triphosphatase of Electrophorus electric organ. I. An associated sodium-activated transphosphorylation.
    J Biol Chem. 1966 Apr 25;241(8):1882-9 PMID: 4223456
  37. Temperature-dependence of activation and inhibition of rat-brain adenosine triphosphatase activated by sodium and potassium ions.
    Biochem J. 1966 Sep;100(3):762-7 PMID: 16742417
  38. The effect of cations, g-strophanthin and oligomycin on the labeling from [32P] ATP of the (Na+ + K+)-activated enzyme system and the effect of cations and g-strophanthin on the labeling from [32P] ITP and 32Pi.
    Biochim Biophys Acta. 1969 Jul 8;185(1):198-219 PMID: 4240323
  39. Kinetics of monovalent ion activation of the (Na+ K+)-dependent adenosine triphosphatase and a model for ion translocation and its inhibition by the cardiac glycosides.
    Arch Biochem Biophys. 1970 Jan;136(1):280-6 PMID: 4244466
  40. Purification and properties of a highly active ouabain-sensitive Na+, K+-dependent adenosinetriphosphatase from cardiac tissue.
    Biochim Biophys Acta. 1966 Nov 15;128(2):380-90 PMID: 4226404
  41. Studies on the partial reactions catalyzed by the (Na++K+)-activated ATPase. 3. Relation of K+-dependent p-nitrophenylphosphatase to Na+ transport in red cell ghosts.
    Biochim Biophys Acta. 1971 Jul 6;241(1):75-88 PMID: 4331046
  42. Acetyl phosphate as a substitute for ATP in (Na + + K + )-dependent ATPase.
    Biochim Biophys Acta. 1971 Jul 6;241(1):57-67 PMID: 4256593
  43. Activation by freezing of (Na++K+)-ATPase in a microsomal fraction from ox kidney cortex.
    Exp Cell Res. 1971 Oct;68(2):347-55 PMID: 4256536
  44. AN EFFLUX OF NINHYDRIN-POSITIVE MATERIAL ASSOCIATED WITH THE OPERATION OF THE NA+ PUMP IN INTACT CRAB NERVE IMMERSED IN NA+-FREE SOLUTIONS.
    Biochim Biophys Acta. 1964 Sep 25;88:458-60 PMID: 14249857
  45. Potassium activated phosphatase from human red blood cells. The mechanism of potassium activation.
    J Physiol. 1969 Jun;202(2):305-27 PMID: 4306542
  46. Molecular weight estimation of membrane bound ATPase by in vacuo radiation inactivation.
    Biochem Biophys Res Commun. 1968 Mar 12;30(5):582-7 PMID: 4230767
  47. Sodium fluxes in internally dialyzed squid axons.
    J Gen Physiol. 1968 Aug;52(2):181-211 PMID: 4970418
  48. Isolation and characterization of a phosphorylated intermediate in the (Na+ + K+) system-dependent ATPase.
    Biochim Biophys Acta. 1966 Apr 12;118(1):106-15 PMID: 4224710
  49. Factors governing movement and distribution of inorganic ions in nerve and muscle.
    Physiol Rev. 1968 Jan;48(1):1-64 PMID: 4865518
  50. Potassium-ion stimulated p-nitrophenylphosphatase activity occurring in a highly specific adenosine triphosphatase preparation from rabbit brain.
    Biochim Biophys Acta. 1966 Mar 28;117(1):42-53 PMID: 4288054
  51. Flexibility of an active center in sodium-plus-potassium adenosine triphosphatase.
    J Gen Physiol. 1969 Jul 1;54(1):306-26 PMID: 19873651
  52. Mutual exclusion of ATP, ADP and g-strophanthin binding to NaK-ATPase.
    Nat New Biol. 1971 Nov 24;234(47):122-4 PMID: 4257111
  53. Partial purification of a soluble (Na+ + K+)--dependent ATPase from rabbit kidney.
    Biochim Biophys Acta. 1970 Mar 17;203(1):124-32 PMID: 4315633
  54. Binding of tritiated digoxin to human red cell ghosts.
    Nature. 1969 Feb 22;221(5182):776 PMID: 4237238
  55. Phosphorylation of a purified (Na + +K + ) adenosine triphosphatase.
    Biochem Biophys Res Commun. 1971 Jun 18;43(6):1259-65 PMID: 4254982
  56. The influence of some cations on an adenosine triphosphatase from peripheral nerves.
    Biochim Biophys Acta. 1957 Feb;23(2):394-401 PMID: 13412736
  57. Potassium fluxes in dialyzed squid axons.
    J Gen Physiol. 1969 Jun;53(6):704-40 PMID: 5795918
  58. Studies on the partial reactions catalyzed by the (Na+ + K+)-activated ATPase. II. Effects of oligomycin and other inhibitors of the ATPase on the p-nitrophenylphosphatase.
    Biochim Biophys Acta. 1971 Jan 5;225(1):20-5 PMID: 4250837
  59. Affinities or apparent affinities of the transport adenosine triphosphatase system.
    J Gen Physiol. 1969 Jul 1;54(1):289-305 PMID: 19873649
  60. Studies on the interaction of ouabain and other cardio-active steroids with sodium-potassium-activated adenosine triphosphatase.
    Mol Pharmacol. 1968 Jul;4(4):324-36 PMID: 4232893
  61. Molecular structure in phospholipid essential to activate (Na+ K+ Mg2+)-dependent ATPase and (K+ Mg2+)-dependent phosphatase of bovine cerebral cortex.
    Biochim Biophys Acta. 1969;193(2):384-93 PMID: 4310927
  62. A second ouabain-sensitive sodium-dependent adenosine triphosphate in brain microsomes.
    J Biol Chem. 1969 Dec 10;244(23):6493-7 PMID: 4242925
  63. The characterization of new energy dependent cation transport processes in red blood cells.
    Ann N Y Acad Sci. 1966 Jul 14;137(2):566-76 PMID: 5229816
  64. The effects of injecting 'energy-rich' phosphate compounds on the active transport of ions in the giant axons of Loligo.
    J Physiol. 1960 Jul;152:561-90 PMID: 13806926
  65. Ouabain-dependent incorporation of 32P from p-nitrophenyl phosphate into a microsomal phosphatase.
    Mol Pharmacol. 1970 Mar;6(2):99-107 PMID: 4313866
  66. Transport across cell membranes.
    Annu Rev Physiol. 1970;32:21-60 PMID: 4244435
  67. Purification and characterization of (Na+ + K+)-ATPase. II. Preparation by zonal centrifugation of highly active (Na+ + K+)-ATPase from the outer medulla of rabbit kidneys.
    Biochim Biophys Acta. 1971 Apr 13;233(2):381-94 PMID: 4326971
  68. On the specificity of the ATP-binding site of (Na+ + K+)-activated ATPase from brain microsomes.
    Biochim Biophys Acta. 1971 Apr 13;233(2):395-403 PMID: 4326972
  69. Acetyl phosphatase in brain microsomes: a partial reaction of Na+ plus K+ ATPase.
    Arch Biochem Biophys. 1967 Mar;119(1):277-81 PMID: 4293189
  70. Transport through biological membranes.
    Annu Rev Physiol. 1967;29:21-58 PMID: 5335433
  71. A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
    J Biol Chem. 1965 Mar;240:1437-45 PMID: 14284759
  72. PHOSPHOLIPID REQUIREMENT OF NA+,K+-ACTIVATED ADENOSINE TRIPHOSPHATASE FROM RAT BRAIN.
    Arch Biochem Biophys. 1964 Oct;108:47-52 PMID: 14233915
  73. Binding of adenosine triphosphate to sodium and potassium ion-stimulated adenosine triphosphatase.
    J Biol Chem. 1971 Sep 10;246(17):5234-40 PMID: 4255317
  74. Facftors affecting the relative magnitudes of the sodium:potassium and sodium:sodium exchanges catalysed by the sodium pump.
    J Physiol. 1967 Sep;192(1):189-216 PMID: 6051803
  75. Binding of ATP to brain microsomal ATPase. Determination of the ATP-binding capacity and the dissociation constant of the enzyme-ATP complex as a function of K+ concentration.
    Biochim Biophys Acta. 1971 Mar 9;233(1):104-16 PMID: 4252903
  76. Preparation from mammallian brain and kidney of the enzyme system involved in active transport of Na ions and K ions.
    Biochim Biophys Acta. 1962 Apr 9;58:314-25 PMID: 13913700
  77. Purification and characterization of (Na+ + K+)-ATPase. I. The influence of detergents on the activity of (Na+ + K+)-ATPase in preparations from the outer medulla of rabbit kidney.
    Biochim Biophys Acta. 1971 Apr 13;233(2):366-80 PMID: 4254310
  78. Biochemical aspects of active transport.
    Annu Rev Biochem. 1967;36:727-56 PMID: 18257736
  79. Some acyl phosphate-like properties of P32-labeled sodium-potassium-activated adenosine triphosphatase.
    Biochem Biophys Res Commun. 1965 Jun 9;19(6):759-64 PMID: 4221032
  80. ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.
    Physiol Rev. 1965 Jul;45:596-617 PMID: 14337569
  81. Lipid pattern and Na(+)-K (+)-dependent adenosine triphosphatase activity in the salt gland of duck before and after adaptation to hypertonic saline.
    J Membr Biol. 1971 Jun;5(2):169-84 PMID: 24173099
  82. Potassium-activated phosphatase from human red blood cells : The asymmetrical effects of K(+), Na (+), Mg (++) and adenosine triphosphate.
    J Membr Biol. 1970 Dec;3(1):14-25 PMID: 24174181
  83. Partial inhibition of the active transport of cations in the giant axons of Loligo.
    J Physiol. 1960 Jul;152:591-600 PMID: 13806925
  84. K+ minus dependent phosphatase activity observed in the presence of both adenosine triphosphate and Na+.
    Biochim Biophys Acta. 1969 Jan 7;171(1):178-85 PMID: 4303196
  85. Membrane current and intracellular sodium changes in a snail neurone during extrusion of injected sodium.
    J Physiol. 1969 Apr;201(2):495-514 PMID: 5780556
  86. On the mechanism of Na plus and K plus-stimulated hydrolysis of adenosine triphosphate. 2. Comparison of nucleotide specificities of Na plus and K plus-activated ATPase and Na plus-dependent phosphorylation of cell membranes.
    Eur J Biochem. 1968 Dec;7(1):102-10 PMID: 4237210
  87. Comparison of lipid effects on K+-Mg2+ activated p-nitrophenyl phosphatase and Na+-K+-Mg2+ activated adenosine triphosphatase of membrane.
    J Neurochem. 1969 Sep;16(9):1301-7 PMID: 4309100
  88. Kinetic studies on a brain microsomal adenosine triphosphatase. Evidence suggesting conformational changes.
    Biochemistry. 1967 Oct;6(10 ):3250-8 PMID: 4228473
  89. Studies on the characterization of the sodium-potassium transport adenosine triphosphatase. VI. Large scale partial purification and properties of a lubrol-solubilized bovine brain enzyme.
    J Biol Chem. 1971 Jan 25;246(2):531-43 PMID: 4250749
  90. Incorporation of inorganic phosphate-32 into a Na+, K+-ATPase preparation: stimulation by ouabain.
    Arch Biochem Biophys. 1968 Sep 20;127(1):187-92 PMID: 4234579
  91. Role of phospholipid in the activation of Na+, Ka+-activated adenosine triphosphatase of beef brain.
    Arch Biochem Biophys. 1965 Sep;111(3):583-92 PMID: 4222275
  92. Molecular weight of Na, K-ATPase approximated by the radiation inactivation method.
    Biochem Biophys Res Commun. 1967 Nov 30;29(4):588-92 PMID: 16496540
  93. Evidence that a phosphorylated intermediate in a brain transport adenosine triphosphatase is an acyl phosphate.
    Proc Natl Acad Sci U S A. 1965 Jul;54(1):177-84 PMID: 4285423
  94. Effects of intracellular adenosine-5'-diphosphate and orthophosphate on the sensitivity of sodium efflux from squid axon to external sodium and potassium.
    J Gen Physiol. 1970 Nov;56(5):583-620 PMID: 5475997
  95. Potassium ions and the binding of cardiac glycosides to mammalian cells.
    Nature. 1970 May 9;226(5245):521-3 PMID: 5442345
  96. The relationship between G-strophanthin-binding capacity and ATPase activity in plasma-membrane fragments from ox brain.
    Biochim Biophys Acta. 1971 Mar 9;233(1):122-32 PMID: 4252905
  97. The effect of magnesium, ATP, P i , and sodium on the inhibition of the (Na + + K + )-activated enzyme system by g-strophanthin.
    Biochim Biophys Acta. 1971 Aug 13;241(2):443-61 PMID: 4258481
Article Info
Journal
Journal of bioenergetics
Abbr.
J Bioenerg
ISSN
0449-5705
DOI
10.1007/BF01516049
Published
1973-01-00
Pages
1-30
Language
English
Region
England
NLM ID
1301714
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01516049
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2