Cooperation of mitochondrial and nuclear genes specifying the mitochondrial genetic apparatus in Neurospora crassa.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 6 ·1972-06-00 ·Pages 1371-4

Barath Z, Küntzel H

Abstract

Enzymes involved in the expression of the mitochondrial genome in Neurospora crassa are induced by chloramphenicol and ethidium bromide, which block transcription and translation of mitochondrial DNA. It is concluded that most, if not all, proteins of the mitochondrial genetic apparatus are coded by nuclear genes, synthesized on cytoplasmic ribosomes, and controlled by a repressor-like mitochondrial gene product. A model explaining the coordination of nuclear and mitochondrial division cycles by repressor control is discussed.

MeSH Terms

Cell Nucleus/enzymology,metabolism Chloramphenicol/pharmacology Chromatography, Gel Electrophoresis, Paper Enzyme Induction/drug effects Ethidium/pharmacology Formates Genes, Regulator Genetic Code Methionine Mitochondria/enzymology,metabolism Neurospora/metabolism Neurospora crassa/metabolism Peptide Chain Elongation, Translational/drug effects RNA/biosynthesis RNA, Transfer Ribosomes/metabolism Tetrahydrofolates Transferases/metabolism

Chemicals

Formates Tetrahydrofolates RNA Chloramphenicol RNA, Transfer Methionine Transferases Ethidium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Barath Z

Küntzel H

References (21)

21 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.6.1371

Published

1972-06-00

Pages

1371-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426704

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.6.1371 PMC Full Text View journal details

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Cooperation of mitochondrial and nuclear genes specifying the mitochondrial genetic apparatus in Neurospora crassa.

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