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PMID: 4244873 Published · ppublish English Journal Article

Response of the jejunal mucosa in adult coeliac disease to oral prednisolone.

Gut ·Vol. 11 ·No. 1 ·1970-01-00 ·Pages 7-14

Wall AJ, Douglas AP, Booth CC, Pearse AG

Abstract

Five patients with adult coeliac disease were treated with prednisolone for four to five weeks while continuing a normal gluten-containing diet. A prompt histological, ultrastructural and enzymic recovery of the jejunal mucosa in all five was accompanied by an incomplete metabolic response in three of four patients tested. These findings are discussed in relation to the possible immunological pathogenesis of coeliac disease.

MeSH Terms
Adenosine Triphosphatases/analysis Adult Aged Alkaline Phosphatase/analysis Aminopeptidases/analysis Celiac Disease/drug therapy,pathology Esterases/analysis Female Histocytochemistry Humans Intestinal Mucosa/drug effects Jejunum/drug effects,enzymology,pathology Lysosomes/enzymology Male Microscopy, Electron Middle Aged Mitochondria/enzymology Prednisolone/pharmacology,therapeutic use
Chemicals
Prednisolone Esterases Alkaline Phosphatase Aminopeptidases Adenosine Triphosphatases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wall A J
Douglas A P
Booth C C
Pearse A G
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37 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.11.1.7
Published
1970-01-00
Pages
7-14
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1411366
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.11.1.7 PMC Full Text View journal details
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