DNA synthesis and differentiation in embryonic kidney mesenchyme in vitro.

Science (New York, N.Y.) ·Vol. 153 ·No. 3742 ·1966-09-16 ·Pages 1387-9

Sobel JS

Abstract

Mitosis accompanies the differentiation of embryonic metanephrogenic mesenchyme in vitro. Inhibition of mitosis by 5-fluorodeoxyuridine, but not by x-rays, is associated with inhibition of differentiation. The difference may be due to the effect of 5-fluorode-oxyuridine on DNA synthesis.

MeSH Terms

Animals Autoradiography Cell Differentiation/drug effects,radiation effects DNA/biosynthesis Floxuridine/pharmacology In Vitro Techniques Kidney/embryology Mice

Chemicals

Floxuridine DNA

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Sobel J S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.153.3742.1387

Published

1966-09-16

Pages

1387-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.153.3742.1387 View journal details

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DNA synthesis and differentiation in embryonic kidney mesenchyme in vitro.

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