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PMID: 4213979 Published · ppublish English Journal Article

Specificity of the protective response induced by the slime layer of Pseudomonas aeruginosa.

The Journal of hygiene ·Vol. 73 ·No. 1 ·1974-08-00 ·Pages 75-84

Mates A, Zand P

Abstract

Active protection against Pseudomonas aeruginosa could be induced in mice by immunization with either the phenol killed cells or the alcohol precipitated fraction of the slime layer, or the ribosomal vaccine preparation. Passive protection could also be induced by injecting into mice antisera prepared in rabbits against these bacteria. This protection was due to the production of antibodies in reaction to the slime layer; the absorption of these antibodies by the slime caused the loss of protection. The fact that mice were also protected by vaccination with strains other than those used for challenging was attributed to the presence of an antigenically similar slime. Passive protection towards a heterologous strain, even one with an antigenically similar slime layer, was dependent on the dose of the challenging injection.

MeSH Terms
Animals Antibody Formation Antigen-Antibody Reactions Antigens, Bacterial Bacterial Vaccines/administration & dosage,therapeutic use Female Hemagglutination Tests Immune Sera/administration & dosage Immunity Immunity, Active Immunity, Maternally-Acquired Immunization, Passive Immunodiffusion Injections, Intraperitoneal Mice Pseudomonas Infections/immunology,prevention & control Pseudomonas aeruginosa/immunology Rabbits/immunology Ribosomes Serotyping Virulence
Chemicals
Antigens, Bacterial Bacterial Vaccines Immune Sera
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mates A
Zand P
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22 references, click to expand
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Article Info
Journal
The Journal of hygiene
Abbr.
J Hyg (Lond)
ISSN
0022-1724
DOI
10.1017/s002217240002386x
Published
1974-08-00
Pages
75-84
Language
English
Region
England
NLM ID
0375374
PMCID
PMC2130552
Subset
IM
External Links
PubMed source DOI: 10.1017/s002217240002386x PMC Full Text View journal details
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