Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin.

Antimicrobial agents and chemotherapy ·Vol. 4 ·No. 2 ·1973-08-00 ·Pages 133-9

Yu PK, Washington JA

Abstract

Kanamycin, BB-K8, and gentamicin were tested in parallel against 1,037 bacterial strains isolated from clinical material. The activity of BB-K8 at 20 mug/ml was comparable to that of gentamicin at 8 mug/ml against Pseudomonas aeruginosa and against Enterobacteriaceae, with the exception of gentamicin-resistant strains of Proteus rettgeri and Providencia stuartii, in which case the activities of BB-K8 and kanamycin were the same. BB-K8 exhibited little or no activity against streptococci. The activity of BB-K8 was affected by pH and inoculum size. A regression graph for inhibition data with a 10-mug disk of BB-K8 was developed, and synergistic activity of penicillin and BB-K8 against Streptococcus faecalis was tested.

MeSH Terms

Aminobutyrates/pharmacology Drug Synergism Enterobacteriaceae/drug effects Enterococcus faecalis/drug effects Gentamicins/pharmacology Kanamycin/pharmacology Microbial Sensitivity Tests Penicillins/pharmacology Pseudomonas aeruginosa/drug effects

Chemicals

Aminobutyrates Gentamicins Penicillins Kanamycin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Yu P K

Washington J A

References (12)

12 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.4.2.133

Published

1973-08-00

Pages

133-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444518

Subset

External Links

PubMed source DOI: 10.1128/AAC.4.2.133 PMC Full Text View journal details

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Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin.

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