Simian model for the evaluation of immunity to influenza.

Infection and immunity ·Vol. 9 ·No. 1 ·1974-01-00 ·Pages 101-5

Berendt RF

Abstract

Rhesus monkeys (Macaca mulatta) exposed to small-particle aerosols of the Aichi strain of type A2 influenza virus responded by shedding virus from the nasopharynx for 7 to 9 days and by seroconversion (hemagglutination inhibition) 8 or 9 days after exposure. After rechallenge with the homologous virus, no replication of the organism was observed, and a serological anamnestic reaction occurred. The data indicate that the rhesus monkey is a useful primate model for evaluating induced immunity to influenza virus infection.

MeSH Terms

Aerosols Animals Disease Models, Animal Erythrocytes/immunology Guinea Pigs/immunology Haplorhini Hemagglutination Inhibition Tests Immunization, Secondary Immunodiffusion Immunoglobulin A/analysis Macaca Mucus/immunology,microbiology Nose Orthomyxoviridae/immunology,isolation & purification Orthomyxoviridae Infections/immunology Pharynx

Chemicals

Aerosols Immunoglobulin A

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Berendt R F

References (12)

12 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.9.1.101-105.1974

Published

1974-01-00

Pages

101-5

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414772

Subset

External Links

PubMed source DOI: 10.1128/iai.9.1.101-105.1974 PMC Full Text View journal details

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