Relevance of antigenicity of Candida albicans growth phases to diagnosis of systemic candidiasis.

British medical journal ·Vol. 4 ·No. 5884 ·1973-10-13 ·Pages 86-7

Evans EG, Richardson MD, Odds FC, Holland KT

Abstract

The antigenicity of the two growth phases of Candida albicans has been compared by using crossed immunoelectrophoresis and double-diffusion techniques. Qualitative and quantitative differences in antigenic composition between the phases have been revealed and moreover a specific mycelial antigenic component demonstrated.It is postulated that the use of specific mycelial antigens for routine diagnostic precipitin testing in patients with suspected systemic candidiasis would give more reliable results than at present obtained with yeast cell antigens.

MeSH Terms

Antigens, Fungal Candida albicans/growth & development,immunology Candidiasis/diagnosis,immunology Humans Immune Sera Immunodiffusion Immunoelectrophoresis Precipitin Tests Precipitins Yeasts/immunology

Chemicals

Antigens, Fungal Immune Sera Precipitins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Evans E G

Richardson M D

Odds F C

Holland K T

References (8)

8 references, click to expand

Studies on nucleic acids and protein contents of Candida albicans and their relationship to dimorphism.
Indian J Exp Biol. 1966 Jan;4(1):51-2 PMID: 5939207
Cell wall composition of the mycelial and blastospore forms of Candida albicans.
J Gen Microbiol. 1968 May;51(3):367-76 PMID: 5657261
Synthesis of nueic acids and proteins in the dimorphic forms of Candida albicans.
Sabouraudia. 1970 Nov;8(3):163-9 PMID: 5496801
Serological evidence of Candida infection after open-heart surgery.
J Med Microbiol. 1969 Nov 4;2(4):463-9 PMID: 5404803
Identification and quantitation of antigens and antibodies by means of quantitative immunoelectrophoresis. A survey of methods.
J Immunol Methods. 1972 Jan;1(2):109-21 PMID: 5079996
Enteric candidiasis. Diagnosis and clinical considerations.
Pediatrics. 1962 Jul;30:71-85 PMID: 14459096
Microbiological studies in Western Samoa. II. The isolation of yeast-like organisms from the mouth, with a note of some dermatophytes isolated from lesions of tinea corporis.
Trans R Soc Trop Med Hyg. 1960 Mar;54:166-70 PMID: 14421414
ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.
Anal Biochem. 1965 Feb;10:358-61 PMID: 14302464

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.4.5884.86

Published

1973-10-13

Pages

86-7

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1587238

Subset

External Links

PubMed source DOI: 10.1136/bmj.4.5884.86 PMC Full Text

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Relevance of antigenicity of Candida albicans growth phases to diagnosis of systemic candidiasis.

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