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PMID: 418906 Published · ppublish fre Comparative Study English Abstract Journal Article

[Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)].

Préparation et activité antitumorale expérimentale d'un nouvel antibiotique semi-synthétique : la diéthoxyacétoxy-14 daunorubicine (33 921 R.P,).

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles ·Vol. 286 ·No. 5 ·1978-02-06 ·Pages 443-6

Maral R, Ducep JB, Farge D, Ponsinet G, Reisdorf D

Abstract

14-diethoxyacetoxy daunorubicin (R.P. 33 921) was chosen among a series of new daunorubicin analogues. Its preparation from daunorubicin and its biological activities are described. It displays an antitumoral activity in mice with a better chemotherapeutic index than daunorubicin and doxorubicin.

MeSH Terms

Animals Antibiotics, Antineoplastic Cells, Cultured DNA/biosynthesis Daunorubicin/analogs & derivatives,chemical synthesis,pharmacology Dogs Doxorubicin/pharmacology Mutagens Neoplasms, Experimental/drug therapy Protein Biosynthesis RNA/biosynthesis Rabbits

Chemicals

Antibiotics, Antineoplastic Mutagens RNA Doxorubicin DNA Daunorubicin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Maral R

Ducep J B

Farge D

Ponsinet G

Reisdorf D

Article Info

Journal

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles

Abbr.

C R Acad Hebd Seances Acad Sci D

Published

1978-02-06

Pages

443-6

Language

fre

Region

France

NLM ID

7501107

Subset

External Links

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[Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)].

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