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PMID: 4187459 Published · ppublish English Journal Article

Circulatory changes and renin secretion in sheep in response to feeding.

The Journal of physiology ·Vol. 204 ·No. 1 ·1969-09-00 ·Pages 15-30

Blair-West JR, Brook AH

Abstract

1. The effect of feeding on the circulation, on renin release and on renal function has been examined in the sheep.2. There was a rapid reduction of plasma volume within 15 min of starting to eat dry feed.3. This was accompanied by an abrupt rise in systolic blood pressure and by a more gradual and prolonged elevation of heart rate.4. Within 30 min of feeding there occurred renal conservation of sodium and water which continued for at least 2-3 hr.5. Renin was released into the circulation of sheep that ate rapidly; slow feeders did not show this response.6. The rise in plasma renin concentration was inhibited by infusing a solution similar in composition to mixed saliva at a rate that prevented the change in plasma volume.7. It is concluded that the rapid transfer of sodium and water from the circulation to the rumen via the saliva during ingestion of dry feed is sufficient to activate the renin/angiotensin system.

MeSH Terms
Animals Blood Circulation Blood Pressure Eating Female Heart Rate Injections, Intravenous Kidney/physiology Male Nutritional Physiological Phenomena Plasma Volume Renin/blood,metabolism Salivation Sheep Sodium/urine Urination gamma-Globulins
Chemicals
gamma-Globulins Sodium Renin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Blair-West J R
Brook A H
References (35)
35 references, click to expand
  1. Dose-dependent opposite effects of angiotensin on renal sodium excretion.
    Lancet. 1965 Nov 13;2(7420):987-8 PMID: 4159217
  2. Control of renin release.
    Physiol Rev. 1967 Jul;47(3):359-82 PMID: 4864539
  3. ANTIDIURETIC HORMONE ACTIVITY IN SHEEP AFTER FEEDING.
    Q J Exp Physiol Cogn Med Sci. 1965 Jan;50:65-78 PMID: 14286602
  4. The renin-angiotensin-aldosterone system in sodium depletion.
    Med J Aust. 1967 Aug 12;2(7):290-3 PMID: 4293019
  5. Characteristic renal excretion patterns in response to physiological, pathological and pharmacological stimuli.
    Clin Chim Acta. 1960 Nov;5:915-37 PMID: 13782234
  6. Neural stimulation of release of renin.
    Circ Res. 1966 Oct;19(4):851-8 PMID: 5917853
  7. Renin release and its role in renal function and the control of salt balance and arterial pressure.
    Fed Proc. 1967 Jan-Feb;26(1):48-54 PMID: 6018928
  8. Effects of beta-adrenergic blockade on the heart rate and energy expenditure of sheep during feeding and during acute cold exposure.
    Can J Physiol Pharmacol. 1968 Jul;46(4):577-83 PMID: 5668202
  9. CONTROL OF RENIN SECRETION.
    Circ Res. 1964 Jul;15:64-76 PMID: 14196207
  10. Infusion of aldosterone, 9-alpha-fluorohydrocortisone and antidiuretic hormone into the renal artery of normal and adrenalectomized, unanesthetized dogs: effect on electrolyte and water excretion.
    Endocrinology. 1958 Jun;62(6):804-15 PMID: 13548099
  11. The effects of varying doses of angiotensin on renal function and blood pressure in man and dogs.
    Clin Sci. 1965 Dec;29(3):489-504 PMID: 4284985
  12. Balances of water and sodium in the rumen during feeding: osmotic stimulation of sodium absorption in the sheep.
    Q J Exp Physiol Cogn Med Sci. 1966 Apr;51(2):79-93 PMID: 5178801
  13. The role of aldosterone in renal sodium conservation during sodium depletion.
    Aust J Exp Biol Med Sci. 1968 Oct;46(5):525-9 PMID: 5696489
  14. Neural contrfl of intrarenal blood flow.
    Am J Physiol. 1968 Nov;215(5):1067-81 PMID: 5687499
  15. The extent of the adrenal influence upon renal electrolyte excretion in the healthy man on a normal diet, and its contribution to the renal changes on standing.
    J Endocrinol. 1962 Jan;23:365-73 PMID: 14474192
  16. Role of the sympathetic nervous system in regulating renin and aldosterone production in man.
    J Clin Invest. 1967 Apr;46(4):599-605 PMID: 6021207
  17. Effect of angiotensin on renal function in the rat.
    Am J Physiol. 1967 May;212(5):1153-7 PMID: 4290473
  18. The effect of aldosterone, cortisol, and corticosterone upon the sodium and potassium content of sheep's parotid saliva.
    J Clin Invest. 1963 Apr;42:484-96 PMID: 13971460
  19. THE RENIN-ANGIOTENSIN SYSTEM.
    Pharmacol Rev. 1965 Jun;17:143-82 PMID: 14298579
  20. ACTION OF RENIN AND ANGIOTENSIN IN THE RENAL HANDLING OF SODIUM AND CHLORIDE IN RABBITS.
    Can Med Assoc J. 1964 Jan 25;90:256-7 PMID: 14111730
  21. The function of antidiuretic hormone in the sheep.
    J Physiol. 1968 Aug;197(3):723-34 PMID: 5666184
  22. Adrenocortical hormones in human hypertension and their relation to angiotensin.
    Circ Res. 1961 May;9:775-91 PMID: 13704360
  23. Changes in the thiosulphate space and some constituents of the blood of sheep after feeding.
    Res Vet Sci. 1968 Jul;9(4):345-9 PMID: 5673810
  24. The effect of angiotensin on renal sodium excretion: studies in normal dogs and in dogs with experimental renal artery stenosis.
    Clin Sci. 1966 Jun;30(3):529-41 PMID: 4288059
  25. CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG.
    Am J Physiol. 1964 Sep;207:537-46 PMID: 14220020
  26. The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs.
    J Physiol. 1966 Aug;185(3):613-26 PMID: 4288206
  27. Adrenergic nervous system in sodium metabolism. II. Effects of guanethidine on the renal response to sodium deprivation in normal man.
    N Engl J Med. 1966 Dec 29;275(26):1466-71 PMID: 5956373
  28. The effect of acute hypovolemia on the release of aldosterone and on the renal excretion of sodium.
    J Clin Invest. 1958 Feb;37(2):232-43 PMID: 13513754
  29. [THE SODIUM CONCENTRATION IN THE MACULA DENSA CELLS AS A REGULATING FACTOR FOR GLOMERULAR FILTRATION (MICROPUNCTURE EXPERIMENTS)].
    Klin Wochenschr. 1965 Apr 15;43:410-3 PMID: 14333330
  30. Effect of chronic hemorrhage on urinary aldosterone-like activity and sodium excretion in dogs.
    Am J Physiol. 1957 Apr;189(1):181-4 PMID: 13424714
  31. The effect of Na+ depletion on the Na+ :K+ ratio of the parotid saliva of the sheep.
    J Physiol. 1956 Mar 28;131(3):516-25 PMID: 13320351
  32. The reproducibility and accuracy of plasma volume estimation in the sheep with both 131I gamma globulin and Evan's blue.
    Aust J Exp Biol Med Sci. 1967 Feb;45(1):51-75 PMID: 4167047
  33. Effects of angiotensin infusion on renal function in the unanesthetized rat.
    Am J Physiol. 1967 Nov;213(5):1205-8 PMID: 4293369
  34. Some postural adjustments of salt and water excretion.
    J Clin Invest. 1954 Aug;33(8):1089-94 PMID: 13183993
  35. Postural augmentation of plasma renin activity. Importance in diagnosis of renovascular hypertension.
    JAMA. 1966 Sep 19;197(12):973-8 PMID: 4288288
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1969.sp008895
Published
1969-09-00
Pages
15-30
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1351590
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1969.sp008895 PMC Full Text View journal details
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