Immunoglobulins and the X-chromosome.

British medical journal ·Vol. 3 ·No. 5668 ·1969-08-23 ·Pages 439-41

Rhodes K, Markham RL, Maxwell PM, Monk-Jones ME

Abstract

Serum levels of immunoglobulins (Ig) G, M, and A were determined in 28 women with an additional X-chromosome (XXX), and in equal numbers of age-matched normal women and men. Mean IgM levels were found to be highest in the XXX group, intermediate in normal women, and lowest in men; these differences were statistically significant. Mean IgM values obtained from seven XXY and three XXXY cases were almost identical with those of normal women and XXX women respectively. No such sex linkage was observed for IgA and IgG levels. These results support the suggestion that the serum level of IgM is related to the number of X chromosomes present.

MeSH Terms

Adult Aged Chromosome Aberrations Female Genes Humans Immunoglobulin G/analysis Immunoglobulin M/analysis Male Middle Aged Sex Chromosomes gamma-Globulins/analysis

Chemicals

Immunoglobulin G Immunoglobulin M gamma-Globulins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Rhodes K

Markham R L

Maxwell P M

Monk-Jones M E

References (9)

9 references, click to expand

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Nature. 1967 Jun 17;214(5094):1224-5 PMID: 4169229
Evidence for the independence of human immunoglobulin class levels.
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Ann Inst Pasteur (Paris). 1967 Apr;112(4):468-75 PMID: 4169541
A genetic defect in "acquired" agammaglobulinemia.
Proc Natl Acad Sci U S A. 1968 Jul;60(3):881-5 PMID: 5243929
Immunological sex differences. A study of patients with rheumatoid arthritis, their relatives, and controls.
Ann Rheum Dis. 1969 Mar;28(2):104-20 PMID: 4180579
[Familial lymphopenia with agammaglobulinemia & severe moniliasis: the essential lymphocytophthisis as a special form of early childhood agammaglobulinemia].
Helv Paediatr Acta. 1958 Oct;13(4):313-38 PMID: 13610252
Gamma-globulin and acquired immunity to human malaria.
Nature. 1961 Nov 25;192:733-7 PMID: 13880318
[Hereditary lymphoplasmocytic dysgenesis ("alymphocytosis with agammaglobulinemia")].
Schweiz Med Wochenschr. 1961 Dec 30;91:1625-33 PMID: 13907792
QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES.
J Immunol. 1965 Jan;94:84-90 PMID: 14253527

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5668.439

Published

1969-08-23

Pages

439-41

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1984225

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5668.439 PMC Full Text

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