Transformation of human lymphocytes: inhibition by homologous alpha globulin.

Science (New York, N.Y.) ·Vol. 159 ·No. 3820 ·1968-03-15 ·Pages 1243-4

Cooperband SR, Bondevik H, Schmid K, Mannick JA

Abstract

An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.

MeSH Terms

Alpha-Globulins/pharmacology Blood Proteins/biosynthesis Cell Differentiation Culture Techniques DNA/biosynthesis Depression, Chemical Diphtheria Toxoid/pharmacology Humans Lectins/antagonists & inhibitors Lymphocytes/immunology Phosphorus Isotopes Serum Albumin, Bovine/antagonists & inhibitors Tetanus Toxoid/pharmacology

Chemicals

Alpha-Globulins Blood Proteins Diphtheria Toxoid Lectins Phosphorus Isotopes Tetanus Toxoid Serum Albumin, Bovine DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Cooperband S R

Bondevik H

Schmid K

Mannick J A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.159.3820.1243

Published

1968-03-15

Pages

1243-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.159.3820.1243 View journal details

Analysis Services

Transformation of human lymphocytes: inhibition by homologous alpha globulin.

Contact

WeChat Official Account