Antiserum to immunoglobulin A: Inhibition of cell-mediated demyelination in tissue culture.

Science (New York, N.Y.) ·Vol. 153 ·No. 3731 ·1966-07-01 ·Pages 75-6

Winkler GF, Arnason BG

Abstract

Lymph node cells from rats immunized with sciatic nerve in Freund's adjuvant demyelinate trigeminal ganglion cultures. Rabbit antiserum to rat immunoglobulin A blocks this cytodestructive event. The antiserum may act by combining with IgA on the lymphoid cell surface, preventing the interaction of cell-bound antibody and tissue anitigen.

MeSH Terms

Animals Culture Techniques Demyelinating Diseases/immunology Hypersensitivity, Delayed/prevention & control Immune Sera/pharmacology Lymph Nodes/cytology Lymphocytes Rabbits Rats Trigeminal Nerve gamma-Globulins

Chemicals

Immune Sera gamma-Globulins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Winkler G F

Arnason B G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.153.3731.75

Published

1966-07-01

Pages

75-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.153.3731.75 View journal details

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Antiserum to immunoglobulin A: Inhibition of cell-mediated demyelination in tissue culture.

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