Tritiated norepinephrine: release from brain slices by electrical stimulation.

Science (New York, N.Y.) ·Vol. 152 ·No. 3729 ·1966-06-17 ·Pages 1630-1

Baldessarini RJ, Kopin IJ

Abstract

Slices of rat brain and heart that had concentrated H(3)-norepinephrine were superfused and electrically stimulated. Stimulation induced a marked release of H(3)-norepinephrine with a threshold and a maximum repsonse. Release also occurred with increased concentrations of potassium, presumably due to neuronal depolarization. Inhibition of electrically induced release occurred with low calcium and with chlorpromazine and pentobarbital.

MeSH Terms

Animals Brain Chemistry Calcium/pharmacology Chlorpromazine/pharmacology Dopamine/metabolism Electric Stimulation Histamine Release In Vitro Techniques Myocardium/metabolism Norepinephrine/metabolism Pentobarbital/pharmacology Potassium/pharmacology Radiometry Rats Tritium

Chemicals

Tritium Pentobarbital Potassium Calcium Chlorpromazine Dopamine Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Baldessarini R J

Kopin I J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.152.3729.1630

Published

1966-06-17

Pages

1630-1

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.152.3729.1630 View journal details

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Tritiated norepinephrine: release from brain slices by electrical stimulation.

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