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PMID: 41521 Published · ppublish English Comparative Study Journal Article

Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals.

The Biochemical journal ·Vol. 182 ·No. 2 ·1979-08-15 ·Pages 625-8

Winterbourn CC

Abstract

Iron--EDTA was shown to catalyse OH. production from H2O2 and ascorbate by a mechanism largely independent of superoxide. When ascorbate and superoxide were both present, the ascorbate mechanism was more important than superoxide as a source of OH., and would appear to be more significantly biologically.

MeSH Terms
Aldehydes/metabolism Ascorbic Acid/metabolism Ethylenes/metabolism Free Radicals Glutathione/metabolism NAD/metabolism NADP/metabolism Oxygen/metabolism Sulfhydryl Compounds/metabolism Superoxides/metabolism
Chemicals
Aldehydes Ethylenes Free Radicals Sulfhydryl Compounds NAD Superoxides NADP Glutathione Ascorbic Acid Oxygen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Winterbourn C C
References (12)
12 references, click to expand
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    FEBS Lett. 1978 Feb 1;86(1):139-42 PMID: 202505
  8. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.
    J Clin Invest. 1973 Mar;52(3):741-4 PMID: 4346473
  9. An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase.
    Proc Natl Acad Sci U S A. 1971 May;68(5):1024-7 PMID: 4995818
  10. A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase.
    J Biol Chem. 1970 Sep 25;245(18):4641-6 PMID: 5466067
  11. Ethylene formation from methional.
    Biochem Biophys Res Commun. 1978 Mar 30;81(2):498-503 PMID: 666768
  12. The mechanism of oxidative hemolysis produced by phenylhydrazine.
    Mol Pharmacol. 1977 Sep;13(5):832-9 PMID: 895719
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1820625
Published
1979-08-15
Pages
625-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1161347
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1820625 PMC Full Text View journal details
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