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PMID: 41519766 Published · aheadofprint English Journal Article

Rho GTPases signaling mediates aggressiveness and differentiation in neuroblastoma tumors.

Cell communication and signaling : CCS ·2026-01-10

Gómez-Muñoz MA, Ojeda-Puertas M, Luna-Ramírez L, Amador-Álvarez A, Rodríguez-Prieto I, Cordero-Varela JA, Pardal R, Vega FM

Abstract

暂无摘要

Keywords
Cdc42 Differentiation Neuroblastoma Prognosis Rho GTPases
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Gómez-Muñoz María A
Department of Medical Physiology and Biophysics, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSICUniversidad de Sevilla), Seville, 41013, Spain. | Present address: Department of Pathology, Smilow Research Center, NYU Grossman School of Medicine, New York, 10016, USA.
Ojeda-Puertas Mónica
Department of Cell Biology, Faculty of Biology, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla), Seville, 41012, Spain.
Luna-Ramírez Luis
Department of Medical Physiology and Biophysics, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSICUniversidad de Sevilla), Seville, 41013, Spain.
Amador-Álvarez Aida
Department of Cell Biology, Faculty of Biology, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla), Seville, 41012, Spain.
Rodríguez-Prieto Ismael
Department of Medical Physiology and Biophysics, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSICUniversidad de Sevilla), Seville, 41013, Spain.
Cordero-Varela Juan A
Bioinformatics and Computational Biology Service, Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla), Seville, 41013, Spain.
Pardal Ricardo
Department of Medical Physiology and Biophysics, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSICUniversidad de Sevilla), Seville, 41013, Spain. rpardal@us.es.
Vega Francisco M
Department of Cell Biology, Faculty of Biology, Universidad de Sevilla and Instituto de Biomedicina de Sevilla (IBiS) (Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla), Seville, 41012, Spain. fmvega@us.es.
Conflict of Interest

Declarations. Ethics approval and consent to participate: All animal experiments were conducted at the facilities of the Instituto de Biomedicina de Sevilla according to procedures approved by the Ethics Committee from the University of Seville and complying with all animal use guidelines. Fresh neuroblastoma tumor samples were managed and obtained from the Andalusian tissue Biobank (Andalusian Public Health System Biobank and ISCIII-Red de Biobancos PT13/0010/0056) after informed consent were obtained from subjects’ guardians, following all established regulations. Clinical information on patient cohorts is available for research use and has been anonymized. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

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Article Info
Journal
Cell communication and signaling : CCS
Abbr.
Cell Commun Signal
ISSN
1478-811X
DOI
10.1186/s12964-025-02649-3
Email
rpardal@us.es
fmvega@us.es
Published
2026-01-10
Epub
2026-00-10
Language
English
Region
England
NLM ID
101170464
PMCID
PMC12882482
Subset
IM
Grants
Ministerio de Ciencia, Innovación y Universidades · PID2022-142424OB-I00
Ministerio de Ciencia e Innovación · PID2019-110817RB-I00
External Links
PubMed source DOI: 10.1186/s12964-025-02649-3 PMC Full Text View journal details
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