Filamentous capsulated streptococci from the human respiratory tract. 3. Immunochemical studies of the cross-reactivity between the cell wall antigens of a filamentous streptococcus and of pneumococcus.

Infection and immunity ·Vol. 8 ·No. 6 ·1973-12-00 ·Pages 969-76

Karakawa WW, Kane JA, Austrian R

Abstract

A cell wall-associated polysaccharide has been isolated from a noncapsulated mutant, 89R50, of the alpha-hemolytic filamentous streptococcus of provisional capsular type 89. Chemical analysis of the polysaccharide indicates that it consists of galactosamine, glucosamine, glucose, and phosphorus. Immunological cross-reactivity was observed between the streptococcal cell wall antigen and antibody to the cell wall-like capsular polysaccharide of pneumococcus. This cross-reactivity appears attributable to similarities in the teichoic acid moieties rather than in the mucopeptide moieties of the two polymers. No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor. It is suggested that antibody to this cell wall polysaccharide might serve as a basis for grouping other filamentous strains of streptococci of diverse capsular types, the cell wall antigens of which show similar cross-reactivity with that of pneumococcus.

MeSH Terms

Antigens, Bacterial/analysis Cell Wall/analysis,immunology Chromatography, DEAE-Cellulose Cross Reactions Galactosamine/analysis Glucosamine/analysis Glucose/analysis Humans Mucoproteins/analysis Mutation Phosphorus/analysis Polysaccharides, Bacterial/analysis,isolation & purification Precipitin Tests Respiratory Tract Infections/microbiology Streptococcus/analysis,cytology,immunology Streptococcus pneumoniae/analysis,immunology Teichoic Acids/analysis

Chemicals

Antigens, Bacterial Mucoproteins Polysaccharides, Bacterial Teichoic Acids Phosphorus Galactosamine Glucose Glucosamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Karakawa W W

Kane J A

Austrian R

References (23)

23 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.8.6.969-976.1973

Published

1973-12-00

Pages

969-76

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422958

Subset

External Links

PubMed source DOI: 10.1128/iai.8.6.969-976.1973 PMC Full Text View journal details

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Filamentous capsulated streptococci from the human respiratory tract. 3. Immunochemical studies of the cross-reactivity between the cell wall antigens of a filamentous streptococcus and of pneumococcus.

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