Gamma-glutamyl transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids.

Science (New York, N.Y.) ·Vol. 184 ·No. 4132 ·1974-04-05 ·Pages 66-8

Orlowski M, Sessa G, Green JP

Abstract

A fraction containing capillaries and rich in gamma-glutamyl transpeptidase was isolated from homogenates of bovine brain cortex by density gradient centrifugation. The enzyme was localized in the endothelial cells by a histochemical procedure. gamma-Glutantyl transpeptidase may function in the transfer of some amino acids across the blood-brain barrier.

MeSH Terms

Alkaline Phosphatase/isolation & purification Amino Acids/metabolism Animals Blood-Brain Barrier Capillaries/enzymology Cattle Centrifugation, Density Gradient Cerebral Cortex/blood supply,enzymology Endothelium/enzymology Nucleotidases/isolation & purification gamma-Glutamyltransferase/isolation & purification,metabolism

Chemicals

Amino Acids gamma-Glutamyltransferase Nucleotidases Alkaline Phosphatase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Orlowski M

Sessa G

Green J P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.184.4132.66

Published

1974-04-05

Pages

66-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.184.4132.66 View journal details

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Gamma-glutamyl transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids.

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