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PMID: 414993 Published · ppublish English Journal Article

Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.

Immunology ·Vol. 34 ·No. 1 ·1978-01-00 ·Pages 77-86

Butcher GA, Mitchell GH, Cohen S

Abstract

Rhesus monkeys vaccinated with merozoites in FCA are protected against challenge with several strains and variants of Plasmodium knowlesi. Vaccination induces sterilizing immunity which is species specific. Merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera provided these contain high levels of inhibitory antibody. However, vaccination using adjuvants other than FCA may induce inhibitory antibody without clinical protection. In addition, vaccinated animals may become susceptible to challenge 4-5 weeks after splenectomy, although inhibitory antibody levels are not reduced. These observations indicate that immunity induced by merozoite vaccination involves: (i) merozoite blocking (inhibitory) antibody, (ii) specific antibody or immune complexes acting synergistically with cytotoxic splenic cells stimulated by FCA.

MeSH Terms
Animals Antibodies/analysis Binding, Competitive Haplorhini Immunization, Passive Macaca mulatta Malaria/immunology Phagocytosis Plasmodium/immunology Splenectomy Vaccination
Chemicals
Antibodies
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Butcher G A
Mitchell G H
Cohen S
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23 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1978-01-00
Pages
77-86
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1457343
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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