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PMID: 4148725 Published · ppublish English Journal Article

Role of peroxide in phagocytic killing of pneumococci.

Infection and immunity ·Vol. 9 ·No. 1 ·1974-01-00 ·Pages 48-52

Pitt J, Bernheimer HP

Abstract

Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.

MeSH Terms
Animals Bacterial Vaccines Blood Bactericidal Activity Humans Immune Sera Leukocytes/immunology Male Peroxides/metabolism Phagocyte Bactericidal Dysfunction/immunology Phagocytosis Rabbits/immunology Streptococcus pneumoniae/immunology,metabolism
Chemicals
Bacterial Vaccines Immune Sera Peroxides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pitt J
Bernheimer H P
References (11)
11 references, click to expand
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    J Exp Med. 1959 Sep 1;110:419-43 PMID: 13811057
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    J Bacteriol. 1969 Oct;100(1):531-2 PMID: 5344114
  8. Improvement of leukocyte bactericidal activity in chronic granulomatous disease.
    Blood. 1970 Mar;35(3):350-5 PMID: 4908653
  9. Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease.
    J Clin Invest. 1970 May;49(5):865-70 PMID: 5441540
  10. Induction of closely linked multiple mutations by nitrosoguanidine.
    Nat New Biol. 1971 Mar 24;230(12):122-5 PMID: 4927375
  11. Iodination defect in the leukocytes of a patient with chronic granulomatous disease of childhood.
    N Engl J Med. 1969 Feb 27;280(9):460-6 PMID: 4974160
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.9.1.48-52.1974
Published
1974-01-00
Pages
48-52
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414763
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.9.1.48-52.1974 PMC Full Text View journal details
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