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PMID: 4146214 Published · ppublish English Journal Article

Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 4 ·1973-04-00 ·Pages 1268-72

Croce CM, Litwack G, Koprowski H

Abstract

The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome.

MeSH Terms
Animals Carcinoma, Hepatocellular Cell Line Clone Cells Dexamethasone/pharmacology Embryo, Mammalian Enzyme Induction/drug effects Enzyme Repression Female Genes, Regulator Genetic Linkage Glucosephosphate Dehydrogenase Humans Hybrid Cells/enzymology Karyotyping Liver Neoplasms Lung Pentosyltransferases Rats Sex Chromosomes Tyrosine Transaminase/biosynthesis
Chemicals
Dexamethasone Glucosephosphate Dehydrogenase Pentosyltransferases Tyrosine Transaminase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Croce C M
Litwack G
Koprowski H
References (18)
18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.4.1268
Published
1973-04-00
Pages
1268-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433473
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.4.1268 PMC Full Text View journal details
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